TY - JOUR
T1 - Zytokine als Marker bei Polytrauma
AU - Van Griensven, M.
PY - 2014/8
Y1 - 2014/8
N2 - Background: Multiple trauma can lead to posttraumatic complications such as systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), and sepsis. Currently, these complications are monitored using clinical and organ-specific parameters. The immune system is activated by trauma. Cytokines, which are the messenger molecules of this system, can be determined in serum. Furthermore, they are associated with the intensity of the inflammatory and anti-inflammatory reactions. Aim: This review describes clinical studies that measured cytokines such as TNF-α, IL-1β, IL-6, IL-8, and IL-10 to prognosticate posttraumatic complications. On the other hand, IL-6 can be helpful in deciding which primary operation to perform, i.e., external fixator or intramedullary nail. Moreover, IL-6 indicates the strength of the immune reaction. Thereby, it may help in determining the optimal time for secondary surgery.
AB - Background: Multiple trauma can lead to posttraumatic complications such as systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), and sepsis. Currently, these complications are monitored using clinical and organ-specific parameters. The immune system is activated by trauma. Cytokines, which are the messenger molecules of this system, can be determined in serum. Furthermore, they are associated with the intensity of the inflammatory and anti-inflammatory reactions. Aim: This review describes clinical studies that measured cytokines such as TNF-α, IL-1β, IL-6, IL-8, and IL-10 to prognosticate posttraumatic complications. On the other hand, IL-6 can be helpful in deciding which primary operation to perform, i.e., external fixator or intramedullary nail. Moreover, IL-6 indicates the strength of the immune reaction. Thereby, it may help in determining the optimal time for secondary surgery.
KW - Complications, posttraumatic
KW - Immune reaction
KW - Multiple organ failure
KW - Sepsis
KW - Systemic inflammatory response syndrome
UR - http://www.scopus.com/inward/record.url?scp=84940294156&partnerID=8YFLogxK
U2 - 10.1007/s00113-013-2543-6
DO - 10.1007/s00113-013-2543-6
M3 - Artikel
C2 - 25116012
AN - SCOPUS:84940294156
SN - 0177-5537
VL - 117
SP - 699
EP - 702
JO - Unfallchirurg
JF - Unfallchirurg
IS - 8
ER -