Abstract
Eighty female SpragueDawley rats weighing 257 g were fed during gravidity a semisynthetic diet containing five vitamin-Be-treatment groups (0.6, 3, 6, 18 and 180 mg/kg diet). The daily food intake was 14 g. During the following lactation the rats of each treatment group were divided into two groups containing 3 and 6 mg vitamin Be. At the 14th day of lactation the dams were decapitated. Parameters for determination of the vitamin-BoStatus were activity of AST and ALT in plasma, erythrocytes and liver. The average activity of AST in plasma was 549 U/l, in erythrocytes 1 939 U/l and liver 106 U/g fresh matter (FM). The increasing vitamin-Bo-Supplementation during gravidity resulted in an elevated activity of AST between lowest and highest treatment group in plasma 56 %, erythrocytes 44 %, and in liver 43 %, respectively. In response to the increasing vitamin-B6-treatment during lactation the activity of AST in plasma increased for 19 %, in erythrocytes for 13 %, and in liver for 24 %, respectively. A low vitamin-Bo-Supply (0.6 mg/kg diet) during gravidity in combination with demand-oriented supply during lactation (6 mg/kg diet) initiated the highest increase of activity. A deficient vitamin-BoSupply during lactation (3 mg/kg diet) could be compensated with optimal vitamin-Bo-Supply during gravidity. The values of ALT-activity showed no significant differences between the graded vitamin-Bo-Supplements, as a result of a high coenzyme saturation.
Translated title of the contribution | Effect of dietary vitamin BO intake levels during gravidity and lactation on the activity of specific transaminases in lactating rats |
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Original language | German |
Pages (from-to) | 282-287 |
Number of pages | 6 |
Journal | Zeitschrift fur Ernahrungswissenschaft |
Volume | 35 |
Issue number | 3 |
DOIs | |
State | Published - 1996 |