Zirkulierender Tissue Faktor und Mikropartikel sind bei Patienten mit tiefer Beinvenenthrombose nicht erhöht

Background: Circulating Tissue Factor (TF) is associated with infl ammation and may contribute to thrombotic events. Aim of this study was to analyze circulating TF activity and proinfl ammatory cytokines in patients with deep venous thrombosis. Patients and methods: Forty-eight patients with deep vein thrombosis and 45 control subjects were included. Venous blood samples were obtained at diagnosis for analysis of TF activity, TF antigen, prothrombin fragment F1+ 2, microparticles (expressing phosphatidylserine and supporting FXa generation), Interleukin (IL)-1beta, IL-6, IL-8, IL-10, IL-12and Tumor-Necrosis-Factor-alpha (TNF). Results: TF antigen, activity and microparticles were similar in both groups: In contrast, a signifi cant increase in plasma IL-6, IL-8 and F1+ 2levels was found in thrombosis. This increase in IL-6 and IL-8 as well as F1+ 2was not correlated with the extent of thrombosis, predisposing factors or onset of symptoms. Conclusions: Circulating TF and microparticles are not elevated in deep venous thrombosis. The increase in IL-6, IL-8 and F1+ 2during thrombosis was not proportional to the extent or predisposing risk factors.