Zirkulierender Tissue Faktor und Mikropartikel sind bei Patienten mit tiefer Beinvenenthrombose nicht erhöht

Translated title of the contribution: Circulating tissue factor and microparticles are not increased in patients with deep vein thrombosis

B. A. Steppich, M. Hassenpflug, S. L. Braun, K. Schömig, O. von Beckerath, N. von Beckerath, H. H. Eckstein, I. Ott

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Background: Circulating Tissue Factor (TF) is associated with infl ammation and may contribute to thrombotic events. Aim of this study was to analyze circulating TF activity and proinfl ammatory cytokines in patients with deep venous thrombosis. Patients and methods: Forty-eight patients with deep vein thrombosis and 45 control subjects were included. Venous blood samples were obtained at diagnosis for analysis of TF activity, TF antigen, prothrombin fragment F1+ 2, microparticles (expressing phosphatidylserine and supporting FXa generation), Interleukin (IL)-1beta, IL-6, IL-8, IL-10, IL-12and Tumor-Necrosis-Factor-alpha (TNF). Results: TF antigen, activity and microparticles were similar in both groups: In contrast, a signifi cant increase in plasma IL-6, IL-8 and F1+ 2levels was found in thrombosis. This increase in IL-6 and IL-8 as well as F1+ 2was not correlated with the extent of thrombosis, predisposing factors or onset of symptoms. Conclusions: Circulating TF and microparticles are not elevated in deep venous thrombosis. The increase in IL-6, IL-8 and F1+ 2during thrombosis was not proportional to the extent or predisposing risk factors.

Translated title of the contributionCirculating tissue factor and microparticles are not increased in patients with deep vein thrombosis
Original languageGerman
Pages (from-to)117-122
Number of pages6
JournalVasa - European Journal of Vascular Medicine
Volume40
Issue number2
DOIs
StatePublished - 2011
Externally publishedYes

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