Zinc-promoted hydrohydrazination of terminal alkynes: An efficient domino synthesis of indoles

Karolin Alex, Annegret Tillack, Nicolle Schwarz, Matthias Beller

Research output: Contribution to journalArticlepeer-review

153 Scopus citations

Abstract

(Chemical Equation Presented) Indole click chemistry: The quest for better catalysts for the intermolecular hydrohydrazination to indoles leads to zinc salts. A simple one-pot synthesis forms indoles from arylhydrazines and terminal alkynes. The pharmacologically relevant indole building blocks are selectively formed in the presence of zinc triflate (Zn(OTf)2) or ZnCl 2 (see scheme).

Original languageEnglish
Pages (from-to)2304-2307
Number of pages4
JournalAngewandte Chemie International Edition in English
Volume47
Issue number12
DOIs
StatePublished - 7 Mar 2008
Externally publishedYes

Keywords

  • Alkynes
  • Hydrohydrazinations
  • Indole
  • Zinc

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