Zinc-catalyzed synthesis of pyrazolines and pyrazoles via hydrohydrazination

Karolin Alex, Annegret Tillack, Nicolle Schwarz, Matthias Beller

Research output: Contribution to journalArticlepeer-review

120 Scopus citations


(Chemical Equation Presented) A novel regioselective synthesis of aryl-substituted pyrazolines and pyrazoles has been developed. Substituted phenylhydrazines react with 3-butynol in the presence of a catalytic amount of zinc triflate to give pyrazoline derivatives. The resulting products are easily oxidized in a one-pot procedure to the corresponding pyrazoles.

Original languageEnglish
Pages (from-to)2377-2379
Number of pages3
JournalOrganic Letters
Issue number12
StatePublished - 2008
Externally publishedYes


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