Zinc-catalyzed reduction of amides: Unprecedented selectivity and functional group tolerance

Shoubhik Das, Daniele Addis, Shaolin Zhou, Kathrin Junge, Matthias Beller

Research output: Contribution to journalArticlepeer-review

303 Scopus citations

Abstract

(Chemical Equation Presented) A novel zinc-catalyzed reduction of tertiary amides was developed. This system shows remarkable chemoselectivity and substrate scope tolerating ester, ether, nitro, cyano, azo, and keto substituents.

Original languageEnglish
Pages (from-to)1770-1771
Number of pages2
JournalJournal of the American Chemical Society
Volume132
Issue number6
DOIs
StatePublished - 2010
Externally publishedYes

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