Zero-growth bioprocesses: A challenge for microbial production strains and bioprocess engineering

Julian Lange, Ralf Takors, Bastian Blombach

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Microbial fermentation of renewable feedstocks is an established technology in industrial biotechnology. Besides strict aerobic or anaerobic modes of operation, novel innovative and industrially applicable fermentation processes were developed connecting the advantages of aerobic and anaerobic conditions in a combined production approach. As a consequence, rapid aerobic biomass formation to high cell densities and subsequent anaerobic high-yield and zero-growth production is realized. Following this strategy, bioprocesses operating with substantial overall yield and productivity can be obtained. Here, we summarize the current knowledge and achievements in such microbial zero-growth production processes and pinpoint to challenges due to the complex adaptation of the cellular metabolism during the cell's passage from aerobiosis to anaerobiosis.

Original languageEnglish
Pages (from-to)27-35
Number of pages9
JournalEngineering in Life Sciences
Issue number1
StatePublished - 1 Jan 2017
Externally publishedYes


  • (micro)Aerobic growth
  • Anaerobic production
  • Corynebacterium glutamicum
  • Escherichia coli
  • Oxygen deprivation


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