TY - JOUR
T1 - Zero-growth bioprocesses
T2 - A challenge for microbial production strains and bioprocess engineering
AU - Lange, Julian
AU - Takors, Ralf
AU - Blombach, Bastian
N1 - Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Microbial fermentation of renewable feedstocks is an established technology in industrial biotechnology. Besides strict aerobic or anaerobic modes of operation, novel innovative and industrially applicable fermentation processes were developed connecting the advantages of aerobic and anaerobic conditions in a combined production approach. As a consequence, rapid aerobic biomass formation to high cell densities and subsequent anaerobic high-yield and zero-growth production is realized. Following this strategy, bioprocesses operating with substantial overall yield and productivity can be obtained. Here, we summarize the current knowledge and achievements in such microbial zero-growth production processes and pinpoint to challenges due to the complex adaptation of the cellular metabolism during the cell's passage from aerobiosis to anaerobiosis.
AB - Microbial fermentation of renewable feedstocks is an established technology in industrial biotechnology. Besides strict aerobic or anaerobic modes of operation, novel innovative and industrially applicable fermentation processes were developed connecting the advantages of aerobic and anaerobic conditions in a combined production approach. As a consequence, rapid aerobic biomass formation to high cell densities and subsequent anaerobic high-yield and zero-growth production is realized. Following this strategy, bioprocesses operating with substantial overall yield and productivity can be obtained. Here, we summarize the current knowledge and achievements in such microbial zero-growth production processes and pinpoint to challenges due to the complex adaptation of the cellular metabolism during the cell's passage from aerobiosis to anaerobiosis.
KW - (micro)Aerobic growth
KW - Anaerobic production
KW - Corynebacterium glutamicum
KW - Escherichia coli
KW - Oxygen deprivation
UR - http://www.scopus.com/inward/record.url?scp=85001736145&partnerID=8YFLogxK
U2 - 10.1002/elsc.201600108
DO - 10.1002/elsc.201600108
M3 - Review article
AN - SCOPUS:85001736145
SN - 1618-0240
VL - 17
SP - 27
EP - 35
JO - Engineering in Life Sciences
JF - Engineering in Life Sciences
IS - 1
ER -