Xenon does not induce contracture in human malignant hyperthermia muscle

C. P. Baur; W. Klingler; K. Jurkat-Rott; G. Froeba; E. Schoch; T. Marx; M. Georgieff; F. Lehmann-Horn

doi:10.1093/bja/85.5.712

Xenon does not induce contracture in human malignant hyperthermia muscle

C. P. Baur
, W. Klingler
, K. Jurkat-Rott
, G. Froeba
, E. Schoch
, T. Marx
, M. Georgieff
, F. Lehmann-Horn

University of Ulm
University Medical Center Ulm and Center of Excellence 'Metabolic Disorders'

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Xenon has many characteristics of an ideal anaesthetic agent. It is not known whether xenon is a safe alternative to the potent inhalational anaesthetics in patients susceptible to malignant hyperthermia (MH). We investigated the effect of xenon, halothane and caffeine on muscle specimens of 31 individuals, referred to the MH Unit of the University of Ulm, and performed genetic epidemiology. Thirteen individuals were classified as MH susceptible and 18 as MH negative. Xenon 70% did not cause an increase in baseline tension of any MH-susceptible muscle specimen in contrast to halothane and caffeine. The evoked twitch response increased transiently in MH-susceptible and normal specimens indicating a mechanism independent of MH susceptibility. These results suggest that xenon, in concentrations up to 70% may be a safe anaesthetic for MH-susceptible patients.

Original language	English
Pages (from-to)	712-716
Number of pages	5
Journal	British Journal of Anaesthesia
Volume	85
Issue number	5
DOIs	https://doi.org/10.1093/bja/85.5.712
State	Published - 2000
Externally published	Yes

Keywords

Anaesthetics inhalational, xenon
Complications, malignant hyperthermia

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10.1093/bja/85.5.712

Cite this

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title = "Xenon does not induce contracture in human malignant hyperthermia muscle",

abstract = "Xenon has many characteristics of an ideal anaesthetic agent. It is not known whether xenon is a safe alternative to the potent inhalational anaesthetics in patients susceptible to malignant hyperthermia (MH). We investigated the effect of xenon, halothane and caffeine on muscle specimens of 31 individuals, referred to the MH Unit of the University of Ulm, and performed genetic epidemiology. Thirteen individuals were classified as MH susceptible and 18 as MH negative. Xenon 70\% did not cause an increase in baseline tension of any MH-susceptible muscle specimen in contrast to halothane and caffeine. The evoked twitch response increased transiently in MH-susceptible and normal specimens indicating a mechanism independent of MH susceptibility. These results suggest that xenon, in concentrations up to 70\% may be a safe anaesthetic for MH-susceptible patients.",

keywords = "Anaesthetics inhalational, xenon, Complications, malignant hyperthermia",

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year = "2000",

doi = "10.1093/bja/85.5.712",

language = "English",

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TY - JOUR

T1 - Xenon does not induce contracture in human malignant hyperthermia muscle

AU - Baur, C. P.

AU - Klingler, W.

AU - Jurkat-Rott, K.

AU - Froeba, G.

AU - Schoch, E.

AU - Marx, T.

AU - Georgieff, M.

AU - Lehmann-Horn, F.

PY - 2000

Y1 - 2000

N2 - Xenon has many characteristics of an ideal anaesthetic agent. It is not known whether xenon is a safe alternative to the potent inhalational anaesthetics in patients susceptible to malignant hyperthermia (MH). We investigated the effect of xenon, halothane and caffeine on muscle specimens of 31 individuals, referred to the MH Unit of the University of Ulm, and performed genetic epidemiology. Thirteen individuals were classified as MH susceptible and 18 as MH negative. Xenon 70% did not cause an increase in baseline tension of any MH-susceptible muscle specimen in contrast to halothane and caffeine. The evoked twitch response increased transiently in MH-susceptible and normal specimens indicating a mechanism independent of MH susceptibility. These results suggest that xenon, in concentrations up to 70% may be a safe anaesthetic for MH-susceptible patients.

AB - Xenon has many characteristics of an ideal anaesthetic agent. It is not known whether xenon is a safe alternative to the potent inhalational anaesthetics in patients susceptible to malignant hyperthermia (MH). We investigated the effect of xenon, halothane and caffeine on muscle specimens of 31 individuals, referred to the MH Unit of the University of Ulm, and performed genetic epidemiology. Thirteen individuals were classified as MH susceptible and 18 as MH negative. Xenon 70% did not cause an increase in baseline tension of any MH-susceptible muscle specimen in contrast to halothane and caffeine. The evoked twitch response increased transiently in MH-susceptible and normal specimens indicating a mechanism independent of MH susceptibility. These results suggest that xenon, in concentrations up to 70% may be a safe anaesthetic for MH-susceptible patients.

KW - Anaesthetics inhalational, xenon

KW - Complications, malignant hyperthermia

UR - https://www.scopus.com/pages/publications/0033759865

U2 - 10.1093/bja/85.5.712

DO - 10.1093/bja/85.5.712

M3 - Article

C2 - 11094586

AN - SCOPUS:0033759865

SN - 0007-0912

VL - 85

SP - 712

EP - 716

JO - British Journal of Anaesthesia

JF - British Journal of Anaesthesia

IS - 5

ER -

Xenon does not induce contracture in human malignant hyperthermia muscle

Abstract

Keywords

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