Wrapping it up: the cell biology of myelination

Mikael Simons; Jacqueline Trotter

doi:10.1016/j.conb.2007.08.003

Wrapping it up: the cell biology of myelination

Mikael Simons, Jacqueline Trotter

Research output: Contribution to journal › Review article › peer-review

179 Scopus citations

Abstract

During nervous system development, oligodendroglia in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS) synthesise large amounts of specific proteins and lipids to generate myelin, a specialised membrane that spirally ensheathes axons and facilitates fast conduction of the action potential. Myelination is initiated after glial processes have attached to the axon and polarisation of the plasma membrane has been triggered. Myelin assembly is a multi-step process that occurs in spatially distinct regions of the cell. We propose that assembly of myelin proteins and lipids starts during their transport through the biosynthetic pathway and continues at the plasma membrane aided by myelin-basic protein (MBP). These sequential processes create the special lipid and protein composition necessary for myelin to perform its insulating function during nerve conduction.

Original language	English
Pages (from-to)	533-540
Number of pages	8
Journal	Current Opinion in Neurobiology
Volume	17
Issue number	5
DOIs	https://doi.org/10.1016/j.conb.2007.08.003
State	Published - Oct 2007
Externally published	Yes

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title = "Wrapping it up: the cell biology of myelination",

abstract = "During nervous system development, oligodendroglia in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS) synthesise large amounts of specific proteins and lipids to generate myelin, a specialised membrane that spirally ensheathes axons and facilitates fast conduction of the action potential. Myelination is initiated after glial processes have attached to the axon and polarisation of the plasma membrane has been triggered. Myelin assembly is a multi-step process that occurs in spatially distinct regions of the cell. We propose that assembly of myelin proteins and lipids starts during their transport through the biosynthetic pathway and continues at the plasma membrane aided by myelin-basic protein (MBP). These sequential processes create the special lipid and protein composition necessary for myelin to perform its insulating function during nerve conduction.",

author = "Mikael Simons and Jacqueline Trotter",

note = "Funding Information: We thank Dirk Fitzner and Robin White for help with the figures. This work was supported by the Deutsche Forschungsgemeinschaft (SFB523, GRK521 to MS; SPP 1111 Cell Polarity and GRK 1044 to JT) and the European Union Framework 6 (Signalling and Traffic to JT). ",

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AU - Simons, Mikael

AU - Trotter, Jacqueline

N1 - Funding Information: We thank Dirk Fitzner and Robin White for help with the figures. This work was supported by the Deutsche Forschungsgemeinschaft (SFB523, GRK521 to MS; SPP 1111 Cell Polarity and GRK 1044 to JT) and the European Union Framework 6 (Signalling and Traffic to JT).

PY - 2007/10

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N2 - During nervous system development, oligodendroglia in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS) synthesise large amounts of specific proteins and lipids to generate myelin, a specialised membrane that spirally ensheathes axons and facilitates fast conduction of the action potential. Myelination is initiated after glial processes have attached to the axon and polarisation of the plasma membrane has been triggered. Myelin assembly is a multi-step process that occurs in spatially distinct regions of the cell. We propose that assembly of myelin proteins and lipids starts during their transport through the biosynthetic pathway and continues at the plasma membrane aided by myelin-basic protein (MBP). These sequential processes create the special lipid and protein composition necessary for myelin to perform its insulating function during nerve conduction.

AB - During nervous system development, oligodendroglia in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS) synthesise large amounts of specific proteins and lipids to generate myelin, a specialised membrane that spirally ensheathes axons and facilitates fast conduction of the action potential. Myelination is initiated after glial processes have attached to the axon and polarisation of the plasma membrane has been triggered. Myelin assembly is a multi-step process that occurs in spatially distinct regions of the cell. We propose that assembly of myelin proteins and lipids starts during their transport through the biosynthetic pathway and continues at the plasma membrane aided by myelin-basic protein (MBP). These sequential processes create the special lipid and protein composition necessary for myelin to perform its insulating function during nerve conduction.

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DO - 10.1016/j.conb.2007.08.003

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VL - 17

SP - 533

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JO - Current Opinion in Neurobiology

JF - Current Opinion in Neurobiology

IS - 5

ER -

Wrapping it up: the cell biology of myelination

Abstract

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