Why Biopolymer Microgels with Dynamically Switchable Properties Would be a Great Tool-Box for the Cultivation of Stem Cells

In this short perspective article, it is asked why – different from their macroscopic bulk counterparts – biopolymer-based microgels with dynamically switchable mechanical properties are basically non-existent. The article pinpoints why such dynamic control over the viscoelasticity of microgels would be desirable for the encapsulation of stem cells, how switchable mechanical properties may be achievable in biopolymer-based microgel systems, and what pitfalls and issues need to be addressed to realize such a complex, engineered microenvironment for cells.