Whole-brain activity maps reveal stereotyped, distributed networks for visuomotor behavior

Ruben Portugues, Claudia E. Feierstein, Florian Engert, Michael B. Orger

Research output: Contribution to journalArticlepeer-review

188 Scopus citations

Abstract

Most behaviors, even simple innate reflexes, are mediated by circuits of neurons spanning areas throughout the brain. However, in most cases, the distribution and dynamics of firing patterns of these neurons during behavior are not known. We imaged activity, with cellular resolution, throughout the whole brains of zebrafish performing the optokinetic response. We found a sparse, broadly distributed network that has an elaborate but ordered pattern, with a bilaterally symmetrical organization. Activity patterns fell into distinct clusters reflecting sensory and motor processing. By correlating neuronal responses with an array of sensory and motor variables, we find that the network can be clearly divided into distinct functional modules. Comparing aligned data from multiple fish, we find that the spatiotemporal activity dynamics and functional organization are highly stereotyped across individuals. These experiments systematically reveal the functional architecture of neural circuits underlying a sensorimotor behavior in a vertebrate brain.

Original languageEnglish
Pages (from-to)1328-1343
Number of pages16
JournalNeuron
Volume81
Issue number6
DOIs
StatePublished - 19 Mar 2014
Externally publishedYes

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