Whole body imaging of mice in under 2 sec with single-sweep volumetric optoacoustic tomography (sSVOT)

Sandeep Kumar Kalva, Xosé Luís Deán-Ben, Michael Reiss, Daniel Razansky

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

Accurate visualization of biological events at scales in the order of seconds requires high frame rate acquisition of image data from living tissues. Yet, fast imaging performance commonly comes at the cost of limited field-of-view (FOV) and reduced image quality. Here we present single-sweep volumetric optoacoustic tomography (sSVOT) for whole-body imaging of mice from head to tail within 1.8 s. sSVOT capitalizes on a custom-made spherical matrix array transducer together with a multi-beam illumination approach, the latter playing a critical role in maximizing the effective FOV. We compare the performance metrics to the previously reported whole-body mouse imaging implementations.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2022
EditorsAlexander A. Oraevsky, Lihong V. Wang
PublisherSPIE
ISBN (Electronic)9781510647916
DOIs
StatePublished - 2022
Externally publishedYes
EventPhotons Plus Ultrasound: Imaging and Sensing 2022 - Virtual, Online
Duration: 20 Feb 202224 Feb 2022

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11960
ISSN (Print)1605-7422

Conference

ConferencePhotons Plus Ultrasound: Imaging and Sensing 2022
CityVirtual, Online
Period20/02/2224/02/22

Keywords

  • contrast agents biodistribution
  • optoacoustic imaging
  • photoacoustic computed tomography
  • whole-body imaging

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