When fat meets the gut—focus on intestinal lipid handling in metabolic health and disease

Magdalena Wit, Jonathan Trujillo-Viera, Akim Strohmeyer, Martin Klingenspor, Mohammed Hankir, Grzegorz Sumara

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

The regular overconsumption of energy-dense foods (rich in lipids and sugars) results in elevated intestinal nutrient absorption and consequently excessive accumulation of lipids in the liver, adipose tissue, skeletal muscles, and other organs. This can eventually lead to obesity and obesity-associated diseases such as type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD), cardiovascular disease, and certain types of cancer, as well as aggravate inflammatory bowel disease (IBD). Therefore, targeting the pathways that regulate intestinal nutrient absorption holds significant therapeutic potential. In this review, we discuss the molecular and cellular mechanisms controlling intestinal lipid handling, their relevance to the development of metabolic diseases, and emerging therapeutic strategies.

Original languageEnglish
Article numbere14742
JournalEMBO Molecular Medicine
Volume14
Issue number5
DOIs
StatePublished - 9 May 2022

Keywords

  • enterocyte
  • fat absorption
  • intestine
  • metabolic diseases
  • triglycerides

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