What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence

Gertrud Mannhaupt; Corinna Montrone; Dirk Haase; Werner Mewes; Verena Aign; Jörg D. Hoheisel; Berthold Fartmann; Gerald Nyakatura; Frank Kempken; Josef Maier; Ulrich Schulte

doi:10.1093/nar/gkg293

What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence

Gertrud Mannhaupt, Corinna Montrone, Dirk Haase, Werner Mewes, Verena Aign, Jörg D. Hoheisel, Berthold Fartmann, Gerald Nyakatura, Frank Kempken, Josef Maier, Ulrich Schulte

Life Sciences

Research output: Contribution to journal › Review article › peer-review

61 Scopus citations

Abstract

The German Neurospora Genome Project has assembled sequences from ordered cosmid and BAC clones of linkage groups II and V of the genome of Neurospora crassa in 13 and 12 contigs, respectively. Including additional sequences located on other linkage groups a total of 12 Mb were subjected to a manual gene extraction and annotation process. The genome comprises a small number of repetitive elements, a low degree of segmental duplications and very few paralogous genes. The analysis of the 3218 identified open reading frames provides a first overview of the protein equipment of a filamentous fungus. Significantly, N.crassa possesses a large variety of metabolic enzymes including a substantial number of enzymes involved in the degradation of complex substrates as well as secondary metabolism. While several of these enzymes are specific for filamentous fungi many are shared exclusively with prokaryotes.

Original language	English
Pages (from-to)	1944-1954
Number of pages	11
Journal	Nucleic Acids Research
Volume	31
Issue number	7
DOIs	https://doi.org/10.1093/nar/gkg293
State	Published - 1 Apr 2003

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abstract = "The German Neurospora Genome Project has assembled sequences from ordered cosmid and BAC clones of linkage groups II and V of the genome of Neurospora crassa in 13 and 12 contigs, respectively. Including additional sequences located on other linkage groups a total of 12 Mb were subjected to a manual gene extraction and annotation process. The genome comprises a small number of repetitive elements, a low degree of segmental duplications and very few paralogous genes. The analysis of the 3218 identified open reading frames provides a first overview of the protein equipment of a filamentous fungus. Significantly, N.crassa possesses a large variety of metabolic enzymes including a substantial number of enzymes involved in the degradation of complex substrates as well as secondary metabolism. While several of these enzymes are specific for filamentous fungi many are shared exclusively with prokaryotes.",

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AU - Mannhaupt, Gertrud

AU - Montrone, Corinna

AU - Haase, Dirk

AU - Mewes, Werner

AU - Aign, Verena

AU - Hoheisel, Jörg D.

AU - Fartmann, Berthold

AU - Nyakatura, Gerald

AU - Kempken, Frank

AU - Maier, Josef

AU - Schulte, Ulrich

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N2 - The German Neurospora Genome Project has assembled sequences from ordered cosmid and BAC clones of linkage groups II and V of the genome of Neurospora crassa in 13 and 12 contigs, respectively. Including additional sequences located on other linkage groups a total of 12 Mb were subjected to a manual gene extraction and annotation process. The genome comprises a small number of repetitive elements, a low degree of segmental duplications and very few paralogous genes. The analysis of the 3218 identified open reading frames provides a first overview of the protein equipment of a filamentous fungus. Significantly, N.crassa possesses a large variety of metabolic enzymes including a substantial number of enzymes involved in the degradation of complex substrates as well as secondary metabolism. While several of these enzymes are specific for filamentous fungi many are shared exclusively with prokaryotes.

AB - The German Neurospora Genome Project has assembled sequences from ordered cosmid and BAC clones of linkage groups II and V of the genome of Neurospora crassa in 13 and 12 contigs, respectively. Including additional sequences located on other linkage groups a total of 12 Mb were subjected to a manual gene extraction and annotation process. The genome comprises a small number of repetitive elements, a low degree of segmental duplications and very few paralogous genes. The analysis of the 3218 identified open reading frames provides a first overview of the protein equipment of a filamentous fungus. Significantly, N.crassa possesses a large variety of metabolic enzymes including a substantial number of enzymes involved in the degradation of complex substrates as well as secondary metabolism. While several of these enzymes are specific for filamentous fungi many are shared exclusively with prokaryotes.

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What's in the genome of a filamentous fungus? Analysis of the Neurospora genome sequence

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