What are the structures of phakellistatin 2 and phakellistatin 4?

Oliver Mechnich, Horst Kessler

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Phakellistatins 2 and 4 are cyclic peptides with cancer cell growth inhibitory properties isolated from the ocean marine sponges Phakellia carteri and Phakellia costata. To verify the proposed structures of natural phakellistatins 2 and 4, the given sequential structures were synthesized and their NMR spectra compared with the natural product. A completely different spectral pattern indicates that the structure of the natural compound should be different in both cases. The synthetic compounds according to the formula of phakellistatin 2 and 4 turned out to be inactive against several human cancer cell lines.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalInternational Journal of Peptide Research and Therapeutics
Volume4
Issue number1
DOIs
StatePublished - 1997

Keywords

  • Cyclic peptides
  • Cytotoxicity
  • NMR spectroscopy

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