TY - JOUR
T1 - Weight gain and increased concentrations of receptor proteins for tumor necrosis factor after patients with symptomatic HIV infection received fortified nutrition support
AU - Süttmann, Ulrich
AU - Ockenga, Johann
AU - Schneider, Heinz
AU - Selberg, Oliver
AU - Schlesinger, Anja
AU - Gallati, Harald
AU - Wolfram, Günther
AU - Deicher, Helmuth
AU - Müller, Manfred J.
PY - 1996
Y1 - 1996
N2 - Objective: To determine whether certain nutrients and dietary factors act as modulators of the immune system and improve the nutritional status of immunocompromised patients. Design: Controlled, double-blind, crossover phase trials of the effects of a fortified formula in patients infected with the human immunodeficiency virus (HIV). Patients consumed a control formula for 4 months and a study formula for 4 months. Subjects: Ten men with symptomatic HIV infection who were following stable medication regimens and had no malignancies, mycobacteriosis, or additional virus infection requiring systemic treatment. Intervention: Formula fortified with α-linolenic acid (1.8 g/ day), arginine (7.8 g/day), and RNA (0.75 g/day) and a standard formula. Main outcome measures: Nutritional status determined by anthropometric, bioelectrical, biochemical, and dietary assessment; energy expenditure determined by indirect calorimetry; disease progression; CD4 lymphocyte counts; HIV p24 antigen plasma concentrations; tumor necrosis factor (TNF) receptor proteins; and compliance control parameters. Statistical analyses performed: Student's t tests for paired and unpaired data. Results: Fortified nutrition resulted in a weight gain (+2.9 kg/ 4 months vs -0.5 kg/4 months with the control formula, P<.05), an incorporation of eicosaenoic acid into erythroeyte cell membranes (+47% of baseline values, P<.05), and increased plasma arginine concentrations (96.8±45.1 vs 51.8±20.9 μmol/L, P<.01). The serum concentrations of the soluble tumor necrosis factor receptor (sTNFR) proteins increased during the study period (sTNFR 55=+0.23 vs -0.40 ng/mL, P<.001; sTNFR 75=+0.90 vs -0.36 ng/mL, P<.01), whereas no changes in CD4+ lymphocyte counts were observed. Conclusion: Increasing dietary intakes of n-3 polyunsaturated fatty acids, L-arginine, and RNA increased body weight, possibly by modulating the negative effects of TNF.
AB - Objective: To determine whether certain nutrients and dietary factors act as modulators of the immune system and improve the nutritional status of immunocompromised patients. Design: Controlled, double-blind, crossover phase trials of the effects of a fortified formula in patients infected with the human immunodeficiency virus (HIV). Patients consumed a control formula for 4 months and a study formula for 4 months. Subjects: Ten men with symptomatic HIV infection who were following stable medication regimens and had no malignancies, mycobacteriosis, or additional virus infection requiring systemic treatment. Intervention: Formula fortified with α-linolenic acid (1.8 g/ day), arginine (7.8 g/day), and RNA (0.75 g/day) and a standard formula. Main outcome measures: Nutritional status determined by anthropometric, bioelectrical, biochemical, and dietary assessment; energy expenditure determined by indirect calorimetry; disease progression; CD4 lymphocyte counts; HIV p24 antigen plasma concentrations; tumor necrosis factor (TNF) receptor proteins; and compliance control parameters. Statistical analyses performed: Student's t tests for paired and unpaired data. Results: Fortified nutrition resulted in a weight gain (+2.9 kg/ 4 months vs -0.5 kg/4 months with the control formula, P<.05), an incorporation of eicosaenoic acid into erythroeyte cell membranes (+47% of baseline values, P<.05), and increased plasma arginine concentrations (96.8±45.1 vs 51.8±20.9 μmol/L, P<.01). The serum concentrations of the soluble tumor necrosis factor receptor (sTNFR) proteins increased during the study period (sTNFR 55=+0.23 vs -0.40 ng/mL, P<.001; sTNFR 75=+0.90 vs -0.36 ng/mL, P<.01), whereas no changes in CD4+ lymphocyte counts were observed. Conclusion: Increasing dietary intakes of n-3 polyunsaturated fatty acids, L-arginine, and RNA increased body weight, possibly by modulating the negative effects of TNF.
UR - http://www.scopus.com/inward/record.url?scp=0030163012&partnerID=8YFLogxK
U2 - 10.1016/S0002-8223(96)00156-3
DO - 10.1016/S0002-8223(96)00156-3
M3 - Article
C2 - 8655902
AN - SCOPUS:0030163012
SN - 0002-8223
VL - 96
SP - 565
EP - 569
JO - Journal of the American Dietetic Association
JF - Journal of the American Dietetic Association
IS - 6
ER -
