Web-based documentation system with exchange of DICOM RT for multicenter clinical studies in particle therapy

Kerstin A. Kessel, Nina Bougatf, Christian Bohn, Uwe Engelmann, Dieter Oetzel, Rolf Bendl, J̈urgen Debus, Stephanie E. Combs

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations


Conducting clinical studies is rather difficult because of the large variety of voluminous datasets, different documentation styles, and various information systems, especially in radiation oncology. In this paper, we describe our development of a web-based documentation system with first approaches of automatic statistical analyses for transnational and multicenter clinical studies in particle therapy. It is possible to have immediate access to all patient information and exchange, store, process, and visualize text data, all types of DICOM images, especially DICOM RT, and any other multimedia data. Accessing the documentation system and submitting clinical data is possible for internal and external users (e.g. referring physicians from abroad, who are seeking the new technique of particle therapy for their patients). Thereby, security and privacy protection is ensured with the encrypted https protocol, client certificates, and an application gateway. Furthermore, all data can be pseudonymized. Integrated into the existing hospital environment, patient data is imported via various interfaces over HL7-messages and DICOM. Several further features replace manual input wherever possible and ensure data quality and entirety. With a form generator, studies can be individually designed to fit specific needs. By including all treated patients (also non-study patients), we gain the possibility for overall large-scale, retrospective analyses. Having recently begun documentation of our first six clinical studies, it has become apparent that the benefits lie in the simplification of research work, better study analyses quality and ultimately, the improvement of treatment concepts by evaluating the effectiveness of particle therapy.

Original languageEnglish
Title of host publicationPhotonic Crystal Materials and Devices X
StatePublished - 2012
Externally publishedYes
EventPhotonic Crystal Materials and Devices X - Brussels, Belgium
Duration: 16 Apr 201219 Apr 2012

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


ConferencePhotonic Crystal Materials and Devices X


  • Clinical studies
  • Documentation system
  • PACS
  • Particle therapy


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