Water–fat Dixon cardiac magnetic resonance fingerprinting

Olivier Jaubert, Gastão Cruz, Aurélien Bustin, Torben Schneider, Begoña Lavin, Peter Koken, Reza Hajhosseiny, Mariya Doneva, Daniel Rueckert, René M. Botnar, Claudia Prieto

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Purpose: Cardiac magnetic resonance fingerprinting (cMRF) has been recently introduced to simultaneously provide T1, T2, and M0 maps. Here, we develop a 3-point Dixon-cMRF approach to enable simultaneous water specific T1, T2, and M0 mapping of the heart and fat fraction (FF) estimation in a single breath-hold scan. Methods: Dixon-cMRF is achieved by combining cMRF with several innovations that were previously introduced for other applications, including a 3-echo GRE acquisition with golden angle radial readout and a high-dimensional low-rank tensor constrained reconstruction to recover the highly undersampled time series images for each echo. Water–fat separation of the Dixon-cMRF time series is performed to allow for water- and fat-specific T1, T2, and M0 estimation, whereas FF estimation is extracted from the M0 maps. Dixon-cMRF was evaluated in a standardized T1–T2 phantom, in a water–fat phantom, and in healthy subjects in comparison to current clinical standards: MOLLI, SASHA, T2-GRASE, and 6-point Dixon proton density FF (PDFF) mapping. Results: Dixon-cMRF water T1 and T2 maps showed good agreement with reference T1 and T2 mapping techniques (R2 > 0.99 and maximum normalized RMSE ~5%) in a standardized phantom. Good agreement was also observed between Dixon-cMRF FF and reference PDFF (R2 > 0.99) and between Dixon-cMRF water T1 and T2 and water selective T1 and T2 maps (R2 > 0.99) in a water–fat phantom. In vivo Dixon-cMRF water T1 values were in good agreement with MOLLI and water T2 values were slightly underestimated when compared to T2-GRASE. Average myocardium septal T1 values were 1129 ± 38 ms, 1026 ± 28 ms, and 1045 ± 32 ms for SASHA, MOLLI, and the proposed water Dixon-cMRF. Average T2 values were 51.7 ± 2.2 ms and 42.8 ± 2.6 ms for T2-GRASE and water Dixon-cMRF, respectively. Dixon-cMRF FF maps showed good agreement with in vivo PDFF measurements (R2 > 0.98) and average FF in the septum was measured at 1.3%. Conclusion: The proposed Dixon-cMRF allows to simultaneously quantify myocardial water T1, water T2, and FF in a single breath-hold scan, enabling multi-parametric T1, T2, and fat characterization. Moreover, reduced T1 and T2 quantification bias caused by water–fat partial volume was demonstrated in phantom experiments.

Original languageEnglish
Pages (from-to)2107-2123
Number of pages17
JournalMagnetic Resonance in Medicine
Volume83
Issue number6
DOIs
StatePublished - 1 Jun 2020
Externally publishedYes

Keywords

  • MR fingerprinting
  • T mapping
  • T mapping
  • cardiac MRI
  • fat fraction
  • water–fat DIXON

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