Was kann die transpupillare thermotherapie (TTT) in der behandlung von flachen posterioren aderhautmelanomen leisten? Eine systematische literaturubersicht

Background: Transpupillary thermotherapy is a relatively new method for the treatment of choroidal melanomas. We present a systematic survey of the current literature. Method: A temperature rise in the tumor ranging from 45- 60°C is achieved by an infrared laser beam delivered through the dilated pupil. With a modified delivery system beam widths between 1 and 3 mm and exposure times of one minute are generated. Thus, tumors of up to 4 mm thickness are treatable. TTT can be used as a single treatment procedure or in combination with brachytherapy. Results: Several studies presented in the literature show a satisfactory local tumor control. However, there is a significant risk of vision threatening side effects like retinal vascular occlusion or retinal traction in selected cases. Conclusion: The TTT is a minimal invasive procedure for the treatment of flat choroidal melanomas of the posterior pole which is capable of achieving a good local tumor control. Studies with more patients and longer follow-up will demonstrate if TTT is also beneficial in the longterm management of choroidal melanomas.