TY - JOUR
T1 - Virus safety of islet cell transplantation from transgenic pigs to marmosets
AU - Plotzki, Elena
AU - Buerck, Lelia Wolf van
AU - Knauf, Yvonne
AU - Becker, Tamara
AU - Maetz-Rensing, Kerstin
AU - Schuster, Marion
AU - Baehr, Andrea
AU - Klymiuk, Nikolai
AU - Wolf, Eckhard
AU - Seissler, Jochen
AU - Denner, Joachim
N1 - Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/6/2
Y1 - 2015/6/2
N2 - Transplantation of pig islet cells for the treatment of diabetes may be a more effective approach compared with the application of insulin. However, before introduction into the clinic, efficacy and safety of this treatment have to be shown. Non-human primate models may be used for this, despite the fact that they are characterised by several limitations. Here we investigate the prevalence of porcine endogenous retroviruses (PERVs), which are present in the genome of all pigs and which may infect human cells, as well as of porcine herpes viruses in donor pigs and their potential transmission to non-human primate recipients. Despite the fact that all three subtypes of PERV were present in all and porcine cytomegalovirus (PCMV) was found in some of the pigs, neither PERVs nor PCMV were found in the recipient animals under the experimental conditions applied. Porcine lymphotropic herpes viruses (PLHV) were not found in the donor pigs, hepatitis E virus (HEV) was not found in the recipients.
AB - Transplantation of pig islet cells for the treatment of diabetes may be a more effective approach compared with the application of insulin. However, before introduction into the clinic, efficacy and safety of this treatment have to be shown. Non-human primate models may be used for this, despite the fact that they are characterised by several limitations. Here we investigate the prevalence of porcine endogenous retroviruses (PERVs), which are present in the genome of all pigs and which may infect human cells, as well as of porcine herpes viruses in donor pigs and their potential transmission to non-human primate recipients. Despite the fact that all three subtypes of PERV were present in all and porcine cytomegalovirus (PCMV) was found in some of the pigs, neither PERVs nor PCMV were found in the recipient animals under the experimental conditions applied. Porcine lymphotropic herpes viruses (PLHV) were not found in the donor pigs, hepatitis E virus (HEV) was not found in the recipients.
KW - Porcine endogenous retroviruses
KW - Porcine hepatitis E virus
KW - Porcine herpes viruses
KW - Virus safety
KW - Xenotransplantation
UR - http://www.scopus.com/inward/record.url?scp=84930439482&partnerID=8YFLogxK
U2 - 10.1016/j.virusres.2015.04.016
DO - 10.1016/j.virusres.2015.04.016
M3 - Article
C2 - 25956348
AN - SCOPUS:84930439482
SN - 0168-1702
VL - 204
SP - 95
EP - 102
JO - Virus Research
JF - Virus Research
ER -
