Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors

Keyphrases

• Matrix metalloproteinase-2 (MMP-2) 100%
• Virtual Screening 100%
• Chemical Optimization 100%
• Binding Matrix 100%
• 2-Arylbenzimidazoles 100%
• Non-zinc Binding 100%
• Matrix Metalloproteinases 33%
• Zinc Ion 33%
• Matrix Metalloproteinase Inhibitors 33%
• Large Families 16%
• Structure-activity Relationship 16%
• Inhibitory Activity 16%
• Tumor Progression 16%
• Endoprotease 16%
• Molecular Dynamics Calculations 16%
• Selective Inhibitor 16%
• Regulatory Role 16%
• Anticancer Treatment 16%
• Enzyme Inhibition 16%
• Catalytic Zinc 16%
• Zinc-binding Group 16%
• Inhibition Activity 16%
• Tumor Invasiveness 16%
• Benzimidazole Scaffold 16%
• Screening Campaign 16%
• Early Generation 16%
• MMP-8 16%
• Pseudopeptides 16%
• Novel Matrix 16%
• Peptide Scaffold 16%
• Privileged Structures 16%
• Molecular Simplification 16%
• Simplification Approaches 16%
• Zinc Chelator 16%
• Fold Increase 16%
• Zinc-dependent 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Virtual Screening 100%
• Gelatinase A 100%
• Zinc Ion 33%
• Matrix Metalloproteinase 33%
• Structure Activity Relationship 16%
• Enzyme Inhibition 16%
• Lead Compound 16%
• Neutrophil Collagenase 16%
• Tumor Growth 16%
• Matrix Metalloproteinase Inhibitor 16%
• Benzimidazole 16%
• Pseudopeptide 16%
• Chelating Agent 16%