TY - JOUR
T1 - Viral Culture and p24 Antigenemia of Human Immunodeficiency Virus (HIV)- Infected Individuals Correlated with Antibody Profiles Determined with Recombinant Polypeptides of All HIV-1 Open-Reading Frames
AU - Baur, Andreas
AU - Vornhagen, Rolf
AU - Korn, Klaus
AU - Sonneborn, Hans H.
AU - Eberlein, Bernadette
AU - Harrer, Thomas
AU - Brockhaus, Wolfgang
AU - Jahn, Gerhard
PY - 1992/3
Y1 - 1992/3
N2 - The association between viral activity and antibody profiles was investigated in 202 individuals infected by the human immunodeficiency virus (HIV) grouped according to their Walter Reed clinical stage. Each study group was subdivided into subjects positive or negative for markers of active viral replication: presence of serum p24 antigen and viral culture. In Western blots using recombinant antigens, sera of HIV-positive individuals with positive viral markers had a significantly lower antibody reactivity to several viral proteins than did individuals without viral markers. Noticeably, proteins of the gag (p24, pi7) and env (gpl20, COOH-terminal part of gp41) open-reading frames revealed a decreased reactivity. The antibody response to the regulatory proteins revealed no or poor association with viral activity in the host. The results suggest that seroreactivity is mainly influenced by factors reflecting the viral activity of an HIV-infected individual, while the clinical stage of the patient is less important. Especially, reductions in antibodies against gpl20 and p17 were useful markers associated with increased viral activity.
AB - The association between viral activity and antibody profiles was investigated in 202 individuals infected by the human immunodeficiency virus (HIV) grouped according to their Walter Reed clinical stage. Each study group was subdivided into subjects positive or negative for markers of active viral replication: presence of serum p24 antigen and viral culture. In Western blots using recombinant antigens, sera of HIV-positive individuals with positive viral markers had a significantly lower antibody reactivity to several viral proteins than did individuals without viral markers. Noticeably, proteins of the gag (p24, pi7) and env (gpl20, COOH-terminal part of gp41) open-reading frames revealed a decreased reactivity. The antibody response to the regulatory proteins revealed no or poor association with viral activity in the host. The results suggest that seroreactivity is mainly influenced by factors reflecting the viral activity of an HIV-infected individual, while the clinical stage of the patient is less important. Especially, reductions in antibodies against gpl20 and p17 were useful markers associated with increased viral activity.
UR - http://www.scopus.com/inward/record.url?scp=0026601304&partnerID=8YFLogxK
U2 - 10.1093/infdis/165.3.419
DO - 10.1093/infdis/165.3.419
M3 - Article
C2 - 1371534
AN - SCOPUS:0026601304
SN - 0022-1899
VL - 165
SP - 419
EP - 426
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -
