Verträglichkeit eines neuen kalzium-alginat-insertes zur kontrollierten medikamentösen therapie am auge

Translated title of the contribution: Tolerance of a new calcium alginate depot for controlled medication of the eye

B. Fuchs-Koelwel, C. Koelwel, A. Göpferich, B. Gabler, E. Wiegrebe, C. P. Lohmann

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Purpose. For an effective pharmaceutical treatment it is necessary in some cases to maintain a constant drug level over a certain period. This cannot be achieved by conventional eye drop application. Therefore, a new insert basically consisting of alginates with a different hydroxyethyl-cellulose (HEC) content was developed. The aim of this study was to evaluate the tolerance of these inserts applied to the conjunctival cul de sac. Methods. 24 healthy volunteers received the insert containing different concentrations of hydroxyethylcellulose (0%, 5%, 30%) for 1 up to 5 days. The eyes have been examined several times (including visual acuity, ocular surface morphology, break-up-time, Schirmer-Tear-Test). Subjective parameters were pain sensations or daily life disturbance. Results. After an initial conjunctival hyperemia and a mild foreign body sensation, the insert was well tolerated. No variations concerning the tolerance between the different concentrations of hydroxyethylcellulose were observed. Conclusion. This study showed good tolerance of the new calcium-alginate-insert applied to the ocular surface for controlled drug release.

Translated title of the contributionTolerance of a new calcium alginate depot for controlled medication of the eye
Original languageGerman
Pages (from-to)496-499
Number of pages4
JournalOphthalmologe
Volume101
Issue number5
DOIs
StatePublished - May 2004
Externally publishedYes

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