Abstract
In a controlled clinical trial, the efficacy of an intravenous combination of cimetidine and pirenzepine (group A: 62 patients) was compared with that of an intragastral administration of a magnesium-aluminium-hydroxide concentrate (group B: 58 patients) in preventing visible and occult upper gastro-intestinal tract bleeding in intensive-care patients. It was found that both forms of therapy had the same favourable effect on the extent and incidence rate of visible and occult gastric bleeding. The antacid was more effective than the cimetidine-pirenzepine combination in raising the pH level to 4 or higher (P < 0.05). Intensive-care patients should, therefore, be treated with the antacid whenever possible, since it is equally effective as the cimetidine-pirenzepine combination in preventing bleeding from the upper gastrointestinal tract, whereas it is superior in elevating that gastric pH. Besides, the use of the antacid is also less costly.
Translated title of the contribution | Cimetidine-pirenzepine versus antacids for the prevention of acute bleeding from the upper gastrointestinal tract |
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Original language | German |
Pages (from-to) | 908-914 |
Number of pages | 7 |
Journal | Deutsche Medizinische Wochenschrift |
Volume | 110 |
Issue number | 23 |
DOIs | |
State | Published - 1985 |
Externally published | Yes |