VERGLEICH VON CIMETIDIN-PIRENZEPIN UND ANTACIDA ZUR STRESSBLUTUNGSPROPHYLAXE BEI INTENSIVPATIENTEN. EINE KONTROLLIERTE KLINISCHE STUDIE AN 120 PATIENTEN

Translated title of the contribution: Cimetidine-pirenzepine versus antacids for the prevention of acute bleeding from the upper gastrointestinal tract

D. Engelhardt, R. Karl, H. J. Kolb, D. Inthorn, N. König, U. Büll, D. Hölzel

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

In a controlled clinical trial, the efficacy of an intravenous combination of cimetidine and pirenzepine (group A: 62 patients) was compared with that of an intragastral administration of a magnesium-aluminium-hydroxide concentrate (group B: 58 patients) in preventing visible and occult upper gastro-intestinal tract bleeding in intensive-care patients. It was found that both forms of therapy had the same favourable effect on the extent and incidence rate of visible and occult gastric bleeding. The antacid was more effective than the cimetidine-pirenzepine combination in raising the pH level to 4 or higher (P < 0.05). Intensive-care patients should, therefore, be treated with the antacid whenever possible, since it is equally effective as the cimetidine-pirenzepine combination in preventing bleeding from the upper gastrointestinal tract, whereas it is superior in elevating that gastric pH. Besides, the use of the antacid is also less costly.

Translated title of the contributionCimetidine-pirenzepine versus antacids for the prevention of acute bleeding from the upper gastrointestinal tract
Original languageGerman
Pages (from-to)908-914
Number of pages7
JournalDeutsche Medizinische Wochenschrift
Volume110
Issue number23
DOIs
StatePublished - 1985
Externally publishedYes

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