Vectorial Catalysis in Surface-Anchored Nanometer-Sized Metal–Organic Frameworks-Based Microfluidic Devices

Anna Lisa Semrau; Philip M. Stanley; Dominik Huber; Michael Schuster; Bauke Albada; Han Zuilhof; Mirza Cokoja; Roland A. Fischer

doi:10.1002/anie.202115100

Vectorial Catalysis in Surface-Anchored Nanometer-Sized Metal–Organic Frameworks-Based Microfluidic Devices

Anna Lisa Semrau, Philip M. Stanley, Dominik Huber, Michael Schuster, Bauke Albada, Han Zuilhof, Mirza Cokoja, Roland A. Fischer

Chair of Inorganic and Organometallic Chemistry

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Vectorial catalysis—controlling multi-step reactions in a programmed sequence and by defined spatial localization in a microscale device—is an enticing goal in bio-inspired catalysis research. However, translating concepts from natural cascade biocatalysis into artificial hierarchical chemical systems remains a challenge. Herein, we demonstrate integration of two different surface-anchored nanometer-sized metal–organic frameworks (MOFs) in a microfluidic device for modelling vectorial catalysis. Catalyst immobilization at defined sections along the microchannel and a two-step cascade reaction was conducted with full conversion after 30 seconds and high turnover frequencies (TOF≈10⁵ h⁻¹).

Original language	English
Article number	e202115100
Journal	Angewandte Chemie International Edition in English
Volume	61
Issue number	8
DOIs	https://doi.org/10.1002/anie.202115100
State	Published - 14 Feb 2022

Keywords

Catalysis
Metal-organic frameworks
Microfluidic devices
Surface anchoring
Vectorial catalysis

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10.1002/anie.202115100

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abstract = "Vectorial catalysis—controlling multi-step reactions in a programmed sequence and by defined spatial localization in a microscale device—is an enticing goal in bio-inspired catalysis research. However, translating concepts from natural cascade biocatalysis into artificial hierarchical chemical systems remains a challenge. Herein, we demonstrate integration of two different surface-anchored nanometer-sized metal–organic frameworks (MOFs) in a microfluidic device for modelling vectorial catalysis. Catalyst immobilization at defined sections along the microchannel and a two-step cascade reaction was conducted with full conversion after 30 seconds and high turnover frequencies (TOF≈105 h−1).",

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AU - Schuster, Michael

AU - Albada, Bauke

AU - Zuilhof, Han

AU - Cokoja, Mirza

AU - Fischer, Roland A.

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AB - Vectorial catalysis—controlling multi-step reactions in a programmed sequence and by defined spatial localization in a microscale device—is an enticing goal in bio-inspired catalysis research. However, translating concepts from natural cascade biocatalysis into artificial hierarchical chemical systems remains a challenge. Herein, we demonstrate integration of two different surface-anchored nanometer-sized metal–organic frameworks (MOFs) in a microfluidic device for modelling vectorial catalysis. Catalyst immobilization at defined sections along the microchannel and a two-step cascade reaction was conducted with full conversion after 30 seconds and high turnover frequencies (TOF≈105 h−1).

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Vectorial Catalysis in Surface-Anchored Nanometer-Sized Metal–Organic Frameworks-Based Microfluidic Devices

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Keywords

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