Vectorial Catalysis in Surface-Anchored Nanometer-Sized Metal–Organic Frameworks-Based Microfluidic Devices

Anna Lisa Semrau, Philip M. Stanley, Dominik Huber, Michael Schuster, Bauke Albada, Han Zuilhof, Mirza Cokoja, Roland A. Fischer

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Vectorial catalysis—controlling multi-step reactions in a programmed sequence and by defined spatial localization in a microscale device—is an enticing goal in bio-inspired catalysis research. However, translating concepts from natural cascade biocatalysis into artificial hierarchical chemical systems remains a challenge. Herein, we demonstrate integration of two different surface-anchored nanometer-sized metal–organic frameworks (MOFs) in a microfluidic device for modelling vectorial catalysis. Catalyst immobilization at defined sections along the microchannel and a two-step cascade reaction was conducted with full conversion after 30 seconds and high turnover frequencies (TOF≈105 h−1).

Original languageEnglish
Article numbere202115100
JournalAngewandte Chemie International Edition in English
Issue number8
StatePublished - 14 Feb 2022


  • Catalysis
  • Metal-organic frameworks
  • Microfluidic devices
  • Surface anchoring
  • Vectorial catalysis


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