Vasodilating Properties of the Stem Bark Extract of Mitragyna ciliata in Rats and Guinea Pigs

A. Dongmo; M. A. Kamanyi; P. V. Tan; M. Bopelet; W. Vierling; H. Wagner

doi:10.1002/ptr.1350

Vasodilating Properties of the Stem Bark Extract of Mitragyna ciliata in Rats and Guinea Pigs

A. Dongmo
, M. A. Kamanyi
, P. V. Tan
, M. Bopelet
, W. Vierling
, H. Wagner

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Mitragyna ciliata is commonly used in traditional medicine for the treatment of inflammation, hypertension, headache, rheumatism, gonorrhoea and broncho-pulmonary diseases. In the present study, the vascular relaxant effect in the rat and guinea-pig was investigated. The extract induced aortic relaxation in a concentration-dependent manner, with an EC₅₀ of 1.3 and 7 μg/mL for the noradrenaline- and KCl-induced contractions, respectively. The relaxant effect of the extract on KCl-induced contractions was five times greater than on noradrenaline-induced contractions. Moreover, the relaxant effect of the extract was higher in rat aortic rings with endothelium (104.67%) than without endothelium (49.44%). Chemical analysis of the extract showed the presence of alkaloids and flavonoids which may be responsible for the antihypertensive properties.

Original language	English
Pages (from-to)	36-39
Number of pages	4
Journal	Phytotherapy Research
Volume	18
Issue number	1
DOIs	https://doi.org/10.1002/ptr.1350
State	Published - Jan 2004
Externally published	Yes

Keywords

Aortic rings
Mitragyna ciliata
Precontracted
Vasodilation

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10.1002/ptr.1350

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title = "Vasodilating Properties of the Stem Bark Extract of Mitragyna ciliata in Rats and Guinea Pigs",

abstract = "Mitragyna ciliata is commonly used in traditional medicine for the treatment of inflammation, hypertension, headache, rheumatism, gonorrhoea and broncho-pulmonary diseases. In the present study, the vascular relaxant effect in the rat and guinea-pig was investigated. The extract induced aortic relaxation in a concentration-dependent manner, with an EC50 of 1.3 and 7 μg/mL for the noradrenaline- and KCl-induced contractions, respectively. The relaxant effect of the extract on KCl-induced contractions was five times greater than on noradrenaline-induced contractions. Moreover, the relaxant effect of the extract was higher in rat aortic rings with endothelium (104.67\%) than without endothelium (49.44\%). Chemical analysis of the extract showed the presence of alkaloids and flavonoids which may be responsible for the antihypertensive properties.",

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author = "A. Dongmo and Kamanyi, \{M. A.\} and Tan, \{P. V.\} and M. Bopelet and W. Vierling and H. Wagner",

year = "2004",

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T1 - Vasodilating Properties of the Stem Bark Extract of Mitragyna ciliata in Rats and Guinea Pigs

AU - Dongmo, A.

AU - Kamanyi, M. A.

AU - Tan, P. V.

AU - Bopelet, M.

AU - Vierling, W.

AU - Wagner, H.

PY - 2004/1

Y1 - 2004/1

N2 - Mitragyna ciliata is commonly used in traditional medicine for the treatment of inflammation, hypertension, headache, rheumatism, gonorrhoea and broncho-pulmonary diseases. In the present study, the vascular relaxant effect in the rat and guinea-pig was investigated. The extract induced aortic relaxation in a concentration-dependent manner, with an EC50 of 1.3 and 7 μg/mL for the noradrenaline- and KCl-induced contractions, respectively. The relaxant effect of the extract on KCl-induced contractions was five times greater than on noradrenaline-induced contractions. Moreover, the relaxant effect of the extract was higher in rat aortic rings with endothelium (104.67%) than without endothelium (49.44%). Chemical analysis of the extract showed the presence of alkaloids and flavonoids which may be responsible for the antihypertensive properties.

AB - Mitragyna ciliata is commonly used in traditional medicine for the treatment of inflammation, hypertension, headache, rheumatism, gonorrhoea and broncho-pulmonary diseases. In the present study, the vascular relaxant effect in the rat and guinea-pig was investigated. The extract induced aortic relaxation in a concentration-dependent manner, with an EC50 of 1.3 and 7 μg/mL for the noradrenaline- and KCl-induced contractions, respectively. The relaxant effect of the extract on KCl-induced contractions was five times greater than on noradrenaline-induced contractions. Moreover, the relaxant effect of the extract was higher in rat aortic rings with endothelium (104.67%) than without endothelium (49.44%). Chemical analysis of the extract showed the presence of alkaloids and flavonoids which may be responsible for the antihypertensive properties.

KW - Aortic rings

KW - Mitragyna ciliata

KW - Precontracted

KW - Vasodilation

UR - https://www.scopus.com/pages/publications/0842334486

U2 - 10.1002/ptr.1350

DO - 10.1002/ptr.1350

M3 - Article

C2 - 14750198

AN - SCOPUS:0842334486

SN - 0951-418X

VL - 18

SP - 36

EP - 39

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 1

ER -

Vasodilating Properties of the Stem Bark Extract of Mitragyna ciliata in Rats and Guinea Pigs

Abstract

Keywords

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