Vasodilating Properties of the Stem Bark Extract of Mitragyna ciliata in Rats and Guinea Pigs

A. Dongmo; M. A. Kamanyi; P. V. Tan; M. Bopelet; W. Vierling; H. Wagner

doi:10.1002/ptr.1350

Vasodilating Properties of the Stem Bark Extract of Mitragyna ciliata in Rats and Guinea Pigs

A. Dongmo, M. A. Kamanyi, P. V. Tan, M. Bopelet, W. Vierling, H. Wagner

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Mitragyna ciliata is commonly used in traditional medicine for the treatment of inflammation, hypertension, headache, rheumatism, gonorrhoea and broncho-pulmonary diseases. In the present study, the vascular relaxant effect in the rat and guinea-pig was investigated. The extract induced aortic relaxation in a concentration-dependent manner, with an EC₅₀ of 1.3 and 7 μg/mL for the noradrenaline- and KCl-induced contractions, respectively. The relaxant effect of the extract on KCl-induced contractions was five times greater than on noradrenaline-induced contractions. Moreover, the relaxant effect of the extract was higher in rat aortic rings with endothelium (104.67%) than without endothelium (49.44%). Chemical analysis of the extract showed the presence of alkaloids and flavonoids which may be responsible for the antihypertensive properties.

Original language	English
Pages (from-to)	36-39
Number of pages	4
Journal	Phytotherapy Research
Volume	18
Issue number	1
DOIs	https://doi.org/10.1002/ptr.1350
State	Published - Jan 2004
Externally published	Yes

Keywords

Aortic rings
Mitragyna ciliata
Precontracted
Vasodilation

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title = "Vasodilating Properties of the Stem Bark Extract of Mitragyna ciliata in Rats and Guinea Pigs",

abstract = "Mitragyna ciliata is commonly used in traditional medicine for the treatment of inflammation, hypertension, headache, rheumatism, gonorrhoea and broncho-pulmonary diseases. In the present study, the vascular relaxant effect in the rat and guinea-pig was investigated. The extract induced aortic relaxation in a concentration-dependent manner, with an EC50 of 1.3 and 7 μg/mL for the noradrenaline- and KCl-induced contractions, respectively. The relaxant effect of the extract on KCl-induced contractions was five times greater than on noradrenaline-induced contractions. Moreover, the relaxant effect of the extract was higher in rat aortic rings with endothelium (104.67%) than without endothelium (49.44%). Chemical analysis of the extract showed the presence of alkaloids and flavonoids which may be responsible for the antihypertensive properties.",

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T1 - Vasodilating Properties of the Stem Bark Extract of Mitragyna ciliata in Rats and Guinea Pigs

AU - Dongmo, A.

AU - Kamanyi, M. A.

AU - Tan, P. V.

AU - Bopelet, M.

AU - Vierling, W.

AU - Wagner, H.

PY - 2004/1

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AB - Mitragyna ciliata is commonly used in traditional medicine for the treatment of inflammation, hypertension, headache, rheumatism, gonorrhoea and broncho-pulmonary diseases. In the present study, the vascular relaxant effect in the rat and guinea-pig was investigated. The extract induced aortic relaxation in a concentration-dependent manner, with an EC50 of 1.3 and 7 μg/mL for the noradrenaline- and KCl-induced contractions, respectively. The relaxant effect of the extract on KCl-induced contractions was five times greater than on noradrenaline-induced contractions. Moreover, the relaxant effect of the extract was higher in rat aortic rings with endothelium (104.67%) than without endothelium (49.44%). Chemical analysis of the extract showed the presence of alkaloids and flavonoids which may be responsible for the antihypertensive properties.

KW - Aortic rings

KW - Mitragyna ciliata

KW - Precontracted

KW - Vasodilation

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Vasodilating Properties of the Stem Bark Extract of Mitragyna ciliata in Rats and Guinea Pigs

Abstract

Keywords

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