Varicella zoster virus is not a disease-relevant antigen in multiple sclerosis

Mark P. Burgoon; Randall J. Cohrs; Jeffrey L. Bennett; Sarah W. Anderson; Alanna M. Ritchie; Sabine Cepok; Bernhard Hemmer; Don Gilden; Gregory P. Owens

doi:10.1002/ana.21605

Varicella zoster virus is not a disease-relevant antigen in multiple sclerosis

Mark P. Burgoon, Randall J. Cohrs, Jeffrey L. Bennett, Sarah W. Anderson, Alanna M. Ritchie, Sabine Cepok, Bernhard Hemmer, Don Gilden, Gregory P. Owens

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Abstract

Herpesvirions and varicella zoster virus (VZV) DNA were recently reported in all 15 cerebrospinal fluid (CSF) samples from patients with relapsing-remitting multiple sclerosis (MS) obtained within 1 week of exacerbation. Using identical electron microscopic and polymerase chain reaction techniques, including additional primer sets representing different regions of the VZV genome, we found no herpesvirions or VZV DNA in MS CSF or acute MS plaques. Although enzyme-linked immunosorbent assay analysis demonstrated a higher titer of VZV antibody in MS CSF than in inflammatory control samples, recombinant antibodies prepared from clonally expanded MS CSF plasma cells did not bind to VZV. VZV is not a disease-relevant antigen in MS.

Original language	English
Pages (from-to)	474-479
Number of pages	6
Journal	Annals of Neurology
Volume	65
Issue number	4
DOIs	https://doi.org/10.1002/ana.21605
State	Published - Apr 2009

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title = "Varicella zoster virus is not a disease-relevant antigen in multiple sclerosis",

abstract = "Herpesvirions and varicella zoster virus (VZV) DNA were recently reported in all 15 cerebrospinal fluid (CSF) samples from patients with relapsing-remitting multiple sclerosis (MS) obtained within 1 week of exacerbation. Using identical electron microscopic and polymerase chain reaction techniques, including additional primer sets representing different regions of the VZV genome, we found no herpesvirions or VZV DNA in MS CSF or acute MS plaques. Although enzyme-linked immunosorbent assay analysis demonstrated a higher titer of VZV antibody in MS CSF than in inflammatory control samples, recombinant antibodies prepared from clonally expanded MS CSF plasma cells did not bind to VZV. VZV is not a disease-relevant antigen in MS.",

author = "Burgoon, {Mark P.} and Cohrs, {Randall J.} and Bennett, {Jeffrey L.} and Anderson, {Sarah W.} and Ritchie, {Alanna M.} and Sabine Cepok and Bernhard Hemmer and Don Gilden and Owens, {Gregory P.}",

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AU - Burgoon, Mark P.

AU - Cohrs, Randall J.

AU - Bennett, Jeffrey L.

AU - Anderson, Sarah W.

AU - Ritchie, Alanna M.

AU - Cepok, Sabine

AU - Hemmer, Bernhard

AU - Gilden, Don

AU - Owens, Gregory P.

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Varicella zoster virus is not a disease-relevant antigen in multiple sclerosis

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