Valproate as an adjunct to antipsychotics for schizophrenia: A systematic review of randomized trials

Anja Basan; Werner Kissling; Stefan Leucht

doi:10.1016/j.schres.2004.01.016

Valproate as an adjunct to antipsychotics for schizophrenia: A systematic review of randomized trials

Anja Basan
, Werner Kissling
, Stefan Leucht

Department of Psychiatry and Psychotherapy

Technical University of Munich
Zucker Hillside Hospital

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Randomized controlled trials comparing valproate (as a sole, or as an adjunctive compound) to placebo for patients with schizophrenia or schizophrenia-like disorders were summarized in a metaanalysis. It was possible to include only five trials (n=379) examining valproate as add-on to antipsychotics in this review. Some of the single studies showed inconsistent beneficial effects on some aspects of response, but no overall superiority of valproate augmentation at study endpoints was shown.

Original language	English
Pages (from-to)	33-37
Number of pages	5
Journal	Schizophrenia Research
Volume	70
Issue number	1
DOIs	https://doi.org/10.1016/j.schres.2004.01.016
State	Published - 1 Sep 2004

Keywords

Add-on treatment
Metaanalysis
Schizophrenia
Valproate
Valproid acid

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10.1016/j.schres.2004.01.016

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abstract = "Randomized controlled trials comparing valproate (as a sole, or as an adjunctive compound) to placebo for patients with schizophrenia or schizophrenia-like disorders were summarized in a metaanalysis. It was possible to include only five trials (n=379) examining valproate as add-on to antipsychotics in this review. Some of the single studies showed inconsistent beneficial effects on some aspects of response, but no overall superiority of valproate augmentation at study endpoints was shown.",

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author = "Anja Basan and Werner Kissling and Stefan Leucht",

note = "Funding Information: The authors wish to thank the editorial team of the Cochrane schizophrenia group, under the auspices of which the review was undertaken (Basan et al., 2003) . The work is part of the German Research Network on Schizophrenia and was funded by the German Federal Ministry for Education and Research BMBF (grant 01 GI 993x).",

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AU - Kissling, Werner

AU - Leucht, Stefan

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KW - Valproid acid

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Valproate as an adjunct to antipsychotics for schizophrenia: A systematic review of randomized trials

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Keywords

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