Valproate as an adjunct to antipsychotics for schizophrenia: A systematic review of randomized trials

Anja Basan, Werner Kissling, Stefan Leucht

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Randomized controlled trials comparing valproate (as a sole, or as an adjunctive compound) to placebo for patients with schizophrenia or schizophrenia-like disorders were summarized in a metaanalysis. It was possible to include only five trials (n=379) examining valproate as add-on to antipsychotics in this review. Some of the single studies showed inconsistent beneficial effects on some aspects of response, but no overall superiority of valproate augmentation at study endpoints was shown.

Original languageEnglish
Pages (from-to)33-37
Number of pages5
JournalSchizophrenia Research
Volume70
Issue number1
DOIs
StatePublished - 1 Sep 2004
Externally publishedYes

Keywords

  • Add-on treatment
  • Metaanalysis
  • Schizophrenia
  • Valproate
  • Valproid acid

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