Abstract
The use of genetically isolated populations can empower next-generation association studies. In this review, we discuss the advantages of this approach and review study design and analytical considerations of genetic association studies focusing on isolates.We cite successful examples of using population isolates in association studies and outline potential ways forward.
| Original language | English |
|---|---|
| Pages (from-to) | 371-377 |
| Number of pages | 7 |
| Journal | Briefings in Functional Genomics |
| Volume | 13 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1 Sep 2014 |
| Externally published | Yes |
Keywords
- Complex disease
- Genetic association studies
- Isolated populations
- Rare variants