Using aqueous ammonia in hydroaminomethylation reactions: Ruthenium-catalyzed synthesis of tertiary amines

Lipeng Wu, Ivana Fleischer, Min Zhang, Qiang Liu, Robert Franke, Ralf Jackstell, Matthias Beller

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The direct synthesis of tertiary amines from ammonia and olefins is presented. Using a combination of Ru3(CO)12 and 2-phosphino-substituted imidazole ligand as catalyst system allows for hydroaminomethylation reactions of bulk aliphatic and functionalized olefins. Tertiary amines are obtained in an atom-efficient domino process in moderate to good isolated yields (45-76%) with excellent regioselectivities (n/iso up to 99:1).

Original languageEnglish
Pages (from-to)3260-3263
Number of pages4
JournalChemSusChem
Volume7
Issue number12
DOIs
StatePublished - Dec 2014
Externally publishedYes

Keywords

  • Amines
  • Homogeneous catalysis
  • Hydroaminomethylation
  • Olefins
  • Ruthenium

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