Use of transgenic mutational test systems in risk assessment of carcinogens.

P. Schmezer; C. Eckert; U. M. Liegibel; R. G. Klein; H. Bartsch

doi:10.1007/978-3-642-46856-8_29

Use of transgenic mutational test systems in risk assessment of carcinogens.

P. Schmezer, C. Eckert, U. M. Liegibel, R. G. Klein, H. Bartsch

German Cancer Research Center

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Two transgenic in vivo mutation assays are described which are based on LacZ (Muta Mouse) and LacI (Big Blue) shuttle vector systems. Their utility has already been explored by a number of investigators including our laboratory. The evaluation of data derived from these assays confirm that they offer a practical method for studying mutagenic activity and mechanism in a wide range of tissues including those of the respiratory and gastrointestinal tract. Therefore, these transgenic mutation assays are valuable tools to assess the organotropic effects of genotoxic carcinogens.

Original language	English
Pages (from-to)	321-330
Number of pages	10
Journal	Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement
Volume	20
DOIs	https://doi.org/10.1007/978-3-642-46856-8_29
State	Published - 1998
Externally published	Yes

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title = "Use of transgenic mutational test systems in risk assessment of carcinogens.",

abstract = "Two transgenic in vivo mutation assays are described which are based on LacZ (Muta Mouse) and LacI (Big Blue) shuttle vector systems. Their utility has already been explored by a number of investigators including our laboratory. The evaluation of data derived from these assays confirm that they offer a practical method for studying mutagenic activity and mechanism in a wide range of tissues including those of the respiratory and gastrointestinal tract. Therefore, these transgenic mutation assays are valuable tools to assess the organotropic effects of genotoxic carcinogens.",

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AU - Eckert, C.

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AU - Klein, R. G.

AU - Bartsch, H.

PY - 1998

Y1 - 1998

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AB - Two transgenic in vivo mutation assays are described which are based on LacZ (Muta Mouse) and LacI (Big Blue) shuttle vector systems. Their utility has already been explored by a number of investigators including our laboratory. The evaluation of data derived from these assays confirm that they offer a practical method for studying mutagenic activity and mechanism in a wide range of tissues including those of the respiratory and gastrointestinal tract. Therefore, these transgenic mutation assays are valuable tools to assess the organotropic effects of genotoxic carcinogens.

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JO - Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement

JF - Archives of toxicology. Supplement. = Archiv für Toxikologie. Supplement

ER -

Use of transgenic mutational test systems in risk assessment of carcinogens.

Abstract

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