Uroguanylin: How the gut got another satiety hormone

Randy J. Seeley; Matthias H. Tschöp

doi:10.1172/JCI58297

Uroguanylin: How the gut got another satiety hormone

Randy J. Seeley
, Matthias H. Tschöp

University of Cincinnati College of Medicine

Research output: Contribution to journal › Comment/debate

25 Scopus citations

Abstract

Prouroguanylin is a gastrointestinal paracrine signal and prohormone that is secreted after nutrient ingestion. In this issue of the JCI Valentino et al. show that prouroguanylin is converted to uroguanylin in the CNS which can activate guanylyl cyclase 2C (GUCY2C) receptors in the brain to reduce food intake in mice. This 16-amino acid residue peptide is a novel component of the gut-brain axis that represents a new and unique opportunity to manipulate gut-brain signaling for therapeutic intervention in obesity.

Original language	English
Pages (from-to)	3384-3386
Number of pages	3
Journal	Journal of Clinical Investigation
Volume	121
Issue number	9
DOIs	https://doi.org/10.1172/JCI58297
State	Published - 1 Sep 2011
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1172/JCI58297

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abstract = "Prouroguanylin is a gastrointestinal paracrine signal and prohormone that is secreted after nutrient ingestion. In this issue of the JCI Valentino et al. show that prouroguanylin is converted to uroguanylin in the CNS which can activate guanylyl cyclase 2C (GUCY2C) receptors in the brain to reduce food intake in mice. This 16-amino acid residue peptide is a novel component of the gut-brain axis that represents a new and unique opportunity to manipulate gut-brain signaling for therapeutic intervention in obesity.",

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AB - Prouroguanylin is a gastrointestinal paracrine signal and prohormone that is secreted after nutrient ingestion. In this issue of the JCI Valentino et al. show that prouroguanylin is converted to uroguanylin in the CNS which can activate guanylyl cyclase 2C (GUCY2C) receptors in the brain to reduce food intake in mice. This 16-amino acid residue peptide is a novel component of the gut-brain axis that represents a new and unique opportunity to manipulate gut-brain signaling for therapeutic intervention in obesity.

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Uroguanylin: How the gut got another satiety hormone

Abstract

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