Untersuchungen zum resorptionsverhalten eines niedermolekularen synthetischen huminstoffes nach einmaliger oraler applikation an der ratte

Translated title of the contribution: Studies concerning the resorption properties of a low molecular humic substance after single oral application to rats

N. Lange, M. Kühnert, A. Haase, H. Höke, B. Seubert

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

By labeling HS 1500 with a radioactive 14C, it was proofen that after oral application and under certain circumstances, low amounts of low molecular humic acids are for a short time absorbed from the gastrointestinal tract. But the biological availibility of the substance is very low (less than 0.1 % of the applied high doses). The plasma concentration curve assumes a first order kinetic for invasion and excretion. After oral application of 500 mg/kg b. w. HS 1500 the half life period was 1.5 hours and maximum plasma concentration was 3 μg/ml. The result obtained indicate that HS 1500 is toxicological riskless after oral administration. Taking into account the pharmacokinetic data, residues of the substance in animal tissues can be ruled out with high significance.

Translated title of the contributionStudies concerning the resorption properties of a low molecular humic substance after single oral application to rats
Original languageGerman
Pages (from-to)134-135
Number of pages2
JournalDeutsche Tierarztliche Wochenschrift
Volume103
Issue number4
StatePublished - 1996
Externally publishedYes

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