UNTERSUCHUNG ZUR BIOKINETIC TUMORAFFINER YTTRIUM-ZUBEREITUNGEN - 2. TEIL

K. Schomacker; B. Hientzsch; W. G. Franke; K. Scheidhauer; A. Scharl; K. Jantsch; S. K. Shukla; G. Limouris; T. Fischer; H. Schicha

doi:10.1055/s-0038-1629749

UNTERSUCHUNG ZUR BIOKINETIC TUMORAFFINER YTTRIUM-ZUBEREITUNGEN - 2. TEIL

Translated title of the contribution: Studies on the biokinetics of tumour-affine yttrium preparations - Part 2

K. Schomacker, B. Hientzsch, W. G. Franke, K. Scheidhauer, A. Scharl, K. Jantsch, S. K. Shukla, G. Limouris, T. Fischer, H. Schicha

University of Cologne

Research output: Contribution to journal › Article › peer-review

Abstract

After demonstrating that the application form ⁸⁷Y-NTA-EDTMP-Ca is superior to the so far used citrate form of yttrium especially regarding the tumour/liver and tumour/bone ratios, the relationships between the concentrations of the components in the ⁸⁷Y-NTA-EDTMP-Ca mixture and the ⁸⁷Y biokinetics were investigated in tumour-bearing mice. The increase of the EDTMP and Ca²⁺ concentrations by several orders of magnitude caused no significant changes of tumour radioactivity but a clear radioactivity decrease in the liver, spleen and bone, respectively. The increase of the NTA concentration led also to a radioactivity decrease in all organs and tissues investigated. A significant radioactivity reduction in the tumour could be observed only after administration of rather high NTA amounts. Considerations of the tumour/background ratios depending on different compositions of the injection mixture showed the possibility of optimizing radionuclide biodistribution.

Translated title of the contribution	Studies on the biokinetics of tumour-affine yttrium preparations - Part 2
Original language	German
Pages (from-to)	207-214
Number of pages	8
Journal	NuklearMedizin
Volume	34
Issue number	5
DOIs	https://doi.org/10.1055/s-0038-1629749
State	Published - 1995
Externally published	Yes

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title = "UNTERSUCHUNG ZUR BIOKINETIC TUMORAFFINER YTTRIUM-ZUBEREITUNGEN - 2. TEIL",

abstract = "After demonstrating that the application form 87Y-NTA-EDTMP-Ca is superior to the so far used citrate form of yttrium especially regarding the tumour/liver and tumour/bone ratios, the relationships between the concentrations of the components in the 87Y-NTA-EDTMP-Ca mixture and the 87Y biokinetics were investigated in tumour-bearing mice. The increase of the EDTMP and Ca2+ concentrations by several orders of magnitude caused no significant changes of tumour radioactivity but a clear radioactivity decrease in the liver, spleen and bone, respectively. The increase of the NTA concentration led also to a radioactivity decrease in all organs and tissues investigated. A significant radioactivity reduction in the tumour could be observed only after administration of rather high NTA amounts. Considerations of the tumour/background ratios depending on different compositions of the injection mixture showed the possibility of optimizing radionuclide biodistribution.",

keywords = "biokinetics, dose distribution, tumours, yttrium isotopes",

author = "K. Schomacker and B. Hientzsch and Franke, {W. G.} and K. Scheidhauer and A. Scharl and K. Jantsch and Shukla, {S. K.} and G. Limouris and T. Fischer and H. Schicha",

year = "1995",

doi = "10.1055/s-0038-1629749",

language = "Deutsch",

volume = "34",

pages = "207--214",

journal = "NuklearMedizin",

issn = "0029-5566",

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TY - JOUR

T1 - UNTERSUCHUNG ZUR BIOKINETIC TUMORAFFINER YTTRIUM-ZUBEREITUNGEN - 2. TEIL

AU - Schomacker, K.

AU - Hientzsch, B.

AU - Franke, W. G.

AU - Scheidhauer, K.

AU - Scharl, A.

AU - Jantsch, K.

AU - Shukla, S. K.

AU - Limouris, G.

AU - Fischer, T.

AU - Schicha, H.

PY - 1995

Y1 - 1995

N2 - After demonstrating that the application form 87Y-NTA-EDTMP-Ca is superior to the so far used citrate form of yttrium especially regarding the tumour/liver and tumour/bone ratios, the relationships between the concentrations of the components in the 87Y-NTA-EDTMP-Ca mixture and the 87Y biokinetics were investigated in tumour-bearing mice. The increase of the EDTMP and Ca2+ concentrations by several orders of magnitude caused no significant changes of tumour radioactivity but a clear radioactivity decrease in the liver, spleen and bone, respectively. The increase of the NTA concentration led also to a radioactivity decrease in all organs and tissues investigated. A significant radioactivity reduction in the tumour could be observed only after administration of rather high NTA amounts. Considerations of the tumour/background ratios depending on different compositions of the injection mixture showed the possibility of optimizing radionuclide biodistribution.

AB - After demonstrating that the application form 87Y-NTA-EDTMP-Ca is superior to the so far used citrate form of yttrium especially regarding the tumour/liver and tumour/bone ratios, the relationships between the concentrations of the components in the 87Y-NTA-EDTMP-Ca mixture and the 87Y biokinetics were investigated in tumour-bearing mice. The increase of the EDTMP and Ca2+ concentrations by several orders of magnitude caused no significant changes of tumour radioactivity but a clear radioactivity decrease in the liver, spleen and bone, respectively. The increase of the NTA concentration led also to a radioactivity decrease in all organs and tissues investigated. A significant radioactivity reduction in the tumour could be observed only after administration of rather high NTA amounts. Considerations of the tumour/background ratios depending on different compositions of the injection mixture showed the possibility of optimizing radionuclide biodistribution.

KW - biokinetics

KW - dose distribution

KW - tumours

KW - yttrium isotopes

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U2 - 10.1055/s-0038-1629749

DO - 10.1055/s-0038-1629749

M3 - Artikel

C2 - 7479096

AN - SCOPUS:0028971328

SN - 0029-5566

VL - 34

SP - 207

EP - 214

JO - NuklearMedizin

JF - NuklearMedizin

IS - 5

ER -

UNTERSUCHUNG ZUR BIOKINETIC TUMORAFFINER YTTRIUM-ZUBEREITUNGEN - 2. TEIL

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