TY - JOUR
T1 - Understanding gibberellic acid signaling-are we there yet?
AU - Schwechheimer, Claus
N1 - Funding Information:
The author apologizes to those colleagues whose work could not be discussed in this article owing to size restrictions. The author wishes to thank Björn C Willige and René Richter for their comments on the manuscript. Relevant work in the laboratory of the author is funded by the Deutsche Forschungsgemeinschaft through the Arabidopsis Functional Genomics Network and the Sonderforschungsbereich 446.
PY - 2008/2
Y1 - 2008/2
N2 - The phytohormone gibberellic acid (GA) controls important aspects of plant growth such as seed germination, elongation growth, and flowering. The key components of the GA signaling pathway have been identified over the past 10 years. The current view is that GA binds to a soluble GID1 receptor, which interacts with the DELLA repressor proteins in a GA-dependent manner and thereby induces DELLA protein degradation via the E3 ubiquitin ligase SCFGID2/SLY1. GA-dependent growth responses can generally be correlated with and be explained by changes in DELLA repressor abundance, where the DELLA repressor exerts a growth restraint that is relieved upon its degradation. However, it is obvious that other mechanisms must exist that control the activity of this pathway. This review discusses recent advances in the understanding of GA signaling, of its homeostasis, and of its cross-talk with other signaling pathways.
AB - The phytohormone gibberellic acid (GA) controls important aspects of plant growth such as seed germination, elongation growth, and flowering. The key components of the GA signaling pathway have been identified over the past 10 years. The current view is that GA binds to a soluble GID1 receptor, which interacts with the DELLA repressor proteins in a GA-dependent manner and thereby induces DELLA protein degradation via the E3 ubiquitin ligase SCFGID2/SLY1. GA-dependent growth responses can generally be correlated with and be explained by changes in DELLA repressor abundance, where the DELLA repressor exerts a growth restraint that is relieved upon its degradation. However, it is obvious that other mechanisms must exist that control the activity of this pathway. This review discusses recent advances in the understanding of GA signaling, of its homeostasis, and of its cross-talk with other signaling pathways.
UR - http://www.scopus.com/inward/record.url?scp=38649107053&partnerID=8YFLogxK
U2 - 10.1016/j.pbi.2007.10.011
DO - 10.1016/j.pbi.2007.10.011
M3 - Review article
C2 - 18077204
AN - SCOPUS:38649107053
SN - 1369-5266
VL - 11
SP - 9
EP - 15
JO - Current Opinion in Plant Biology
JF - Current Opinion in Plant Biology
IS - 1
ER -