Ultrahigh resolution in proton solid-state NMR spectroscopy at high levels of deuteration

Veniamin Chevelkov, Kristina Rehbein, Anne Diehl, Bernd Reif

Research output: Contribution to journalArticlepeer-review

278 Scopus citations

Abstract

(Figure Presented) Slim peaks: Using a perdeuterated protein recrystallized from a 10:90 H2O:D2O mixture in magic-angle spinning (MAS) solid-state NMR spectroscopy experiments gives small 1H line widths at moderate spinning frequencies without application of homonuclear decoupling. This labeling strategy opens new perspectives for assignment of large protein spin systems.

Original languageEnglish
Pages (from-to)3878-3881
Number of pages4
JournalAngewandte Chemie International Edition in English
Volume45
Issue number23
DOIs
StatePublished - 2 Jun 2006
Externally publishedYes

Keywords

  • Line widths
  • Magic-angle spinning
  • Predeuteration
  • Proteins
  • Solid-state NMR spectroscopy
  • Structure elucidation

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