Ultra-Fast Synthesis of Multivalent Radical Nanoparticles by Ring-Opening Metathesis Polymerization-Induced Self-Assembly

Dao Le, Marco Dilger, Vincent Pertici, Silvia Diabaté, Didier Gigmes, Carsten Weiss, Guillaume Delaittre

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

We report the straightforward, time-efficient synthesis of radical core–shell nanoparticles (NPs) by polymerization-induced self-assembly. A nitroxide-containing hydrophilic macromolecular precursor was prepared by ring-opening metathesis copolymerization of norbornenyl derivatives of TEMPO and oligoethylene glycol and was chain-extended in situ with norbornene in ethanolic solution, leading to simultaneous amphiphilic block copolymer formation and self-assembly. Without any intermediate purification from the monomers to the block copolymers, radical NPs with tunable diameters ranging from 10 to 110 nm are obtained within minutes at room temperature. The high activity of the radical NPs as chemoselective and homogeneous, yet readily recyclable catalysts is demonstrated through oxidation of a variety of alcohols and recovery by simple centrifugation. Furthermore, the NPs show biocompatibility and antioxidant activity in vitro.

Original languageEnglish
Pages (from-to)4725-4731
Number of pages7
JournalAngewandte Chemie International Edition in English
Volume58
Issue number14
DOIs
StatePublished - 26 Mar 2019
Externally publishedYes

Keywords

  • ROMPISA
  • antioxidants
  • biocompatibility
  • oxidation
  • radical nanoparticles

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