Type 2C protein phosphatases in plants

Stefan Fuchs, Erwin Grill, Irute Meskiene, Alois Schweighofer

Research output: Contribution to journalReview articlepeer-review

184 Scopus citations

Abstract

Type 2C protein phosphatases (PP2Cs) form a structurally unique class of Mg2+-/Mn2+-dependent enzymes. PP2Cs are evolutionary conserved from prokaryotes to higher eukaryotes and play a prominent role in stress signalling. In this review, we focus on the evolution, function and regulation of the plant PP2Cs. Members of a subclass of plant PP2Cs counteract mitogen-activated protein kinase pathways, whereas members of other subfamilies function as co-receptors for the phytohormone abscisic acid. Recent structural analyses of abscisic acid receptors have elucidated the mode of ligand-dependent regulation and substrate targeting.

Original languageEnglish
Pages (from-to)681-693
Number of pages13
JournalFEBS Journal
Volume280
Issue number2
DOIs
StatePublished - Jan 2013

Keywords

  • ABA
  • MAPK
  • PP2C
  • PYR/PYL
  • RCAR
  • phytohormone
  • signalling
  • stress response

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