Abstract
Type 2C protein phosphatases (PP2Cs) form a structurally unique class of Mg2+-/Mn2+-dependent enzymes. PP2Cs are evolutionary conserved from prokaryotes to higher eukaryotes and play a prominent role in stress signalling. In this review, we focus on the evolution, function and regulation of the plant PP2Cs. Members of a subclass of plant PP2Cs counteract mitogen-activated protein kinase pathways, whereas members of other subfamilies function as co-receptors for the phytohormone abscisic acid. Recent structural analyses of abscisic acid receptors have elucidated the mode of ligand-dependent regulation and substrate targeting.
Original language | English |
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Pages (from-to) | 681-693 |
Number of pages | 13 |
Journal | FEBS Journal |
Volume | 280 |
Issue number | 2 |
DOIs | |
State | Published - Jan 2013 |
Keywords
- ABA
- MAPK
- PP2C
- PYR/PYL
- RCAR
- phytohormone
- signalling
- stress response