Type 2 diabetes

Eleftheria Zeggini, Mark I. McCarthy

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

This chapter discusses the genetics of type 2 diabetes (T2D). T2D represents one of the most important causes of global morbidity and mortality. On current projections, the prevalence of this condition will double within a generation, with most of this increase occurring in the countries least well equipped to deal with the social and economic consequences. These rapid changes in prevalence clearly reflect global shifts in lifestyle (greater caloric intake and reduced energy expenditure) that are closely linked to rising rates of obesity. Nevertheless, twin and family studies have repeatedly demonstrated that individual predisposition to T2D has a substantial genetic component. Identification of the genes and variants responsible for these predisposition effects provides valuable insights into pathogenesis; these should, in turn, spur translational advances in clinical care, including the development of novel therapeutic and diagnostic approaches. In addition, it may well become increasingly possible to use personal genetic profile information as a means toward more targeted, individualized clinical management.

Original languageEnglish
Title of host publicationHuman Genome Epidemiology
Subtitle of host publicationBuilding the Evidence for Using Genetic Information to Improve Health and Prevent Disease: Second Edition
PublisherOxford University Press
ISBN (Electronic)9780199776023
ISBN (Print)9780195398441
DOIs
StatePublished - 1 May 2010
Externally publishedYes

Keywords

  • Genetic variants
  • Genetic variations
  • Genome-wide studies
  • Human disease
  • Type 2 diabetes

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