Two different types of potassium channels in human skeletal muscle activated by potassium channel openers

S. Quasthoff, C. Franke, H. Hatt, M. Richter-Turtur

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The inside-out patch clamp technique was used to record the effects of K+ channel openers (EMD 52692, RP 49356 and Cromakalim) on single channel currents in membrane blebs of human skeletal muscle. Two types of K+ channels were activated by these drugs: an ATP-sensitive K+ channel which was inhibited by 3 mM ATP and 5 μM Glibenclamide and an ATP insensitive K+ channel. The open probability of both types was strongly increased by K+ channel openers. Glibenclamide antagonized the action of the K+ channel openers.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalNeuroscience Letters
Volume119
Issue number2
DOIs
StatePublished - 13 Nov 1990

Keywords

  • ATP-sensitive K channel
  • Cromakalim
  • EMD 52692
  • Inside-out patch
  • Membrane bleb
  • Potassium channel opener
  • RP 49356

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