Abstract
The inside-out patch clamp technique was used to record the effects of K+ channel openers (EMD 52692, RP 49356 and Cromakalim) on single channel currents in membrane blebs of human skeletal muscle. Two types of K+ channels were activated by these drugs: an ATP-sensitive K+ channel which was inhibited by 3 mM ATP and 5 μM Glibenclamide and an ATP insensitive K+ channel. The open probability of both types was strongly increased by K+ channel openers. Glibenclamide antagonized the action of the K+ channel openers.
Original language | English |
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Pages (from-to) | 191-194 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 119 |
Issue number | 2 |
DOIs | |
State | Published - 13 Nov 1990 |
Keywords
- ATP-sensitive K channel
- Cromakalim
- EMD 52692
- Inside-out patch
- Membrane bleb
- Potassium channel opener
- RP 49356