Abstract
The tumours of the disseminated/diffuse neuroendocrine cell system are a group of neoplasms sharing uniformly appearing cells which differ from each other in their biology, prognosis and genetics. In the lung they are called carcinoid and small/large-cell neuroendocrine carcinomas. In the gastroenteropancreatic compartment they are classified as well-differentiated neuroendocrine tumours or carcinomas and poorly differentiated neuroendocrine carcinomas. Depending on their localization these neoplasms reveal distinct phenotypes with respect to pathology, immunohistochemistry, and hormonal syndromes. Their clinical behaviour - ranging from benign and low-grade to high-grade malignancy - can be predicted on the basis of clinicopathological criteria. Currently extensive work is being performed to unravel the genetic background.
| Original language | English |
|---|---|
| Pages (from-to) | 15-31 |
| Number of pages | 17 |
| Journal | Best Practice and Research: Clinical Endocrinology and Metabolism |
| Volume | 21 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 2007 |
| Externally published | Yes |
Keywords
- classification
- neuroendocrine tumours
- prognosis
- staging
- typing
