Tumour biology and histopathology of neuroendocrine tumours

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154 Scopus citations


The tumours of the disseminated/diffuse neuroendocrine cell system are a group of neoplasms sharing uniformly appearing cells which differ from each other in their biology, prognosis and genetics. In the lung they are called carcinoid and small/large-cell neuroendocrine carcinomas. In the gastroenteropancreatic compartment they are classified as well-differentiated neuroendocrine tumours or carcinomas and poorly differentiated neuroendocrine carcinomas. Depending on their localization these neoplasms reveal distinct phenotypes with respect to pathology, immunohistochemistry, and hormonal syndromes. Their clinical behaviour - ranging from benign and low-grade to high-grade malignancy - can be predicted on the basis of clinicopathological criteria. Currently extensive work is being performed to unravel the genetic background.

Original languageEnglish
Pages (from-to)15-31
Number of pages17
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Issue number1
StatePublished - Mar 2007
Externally publishedYes


  • classification
  • neuroendocrine tumours
  • prognosis
  • staging
  • typing


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