Tumoral stem cell reprogramming as a driver of cancer: Theory, biological models, implications in cancer therapy

Carolina Vicente-Dueñas; Julia Hauer; Lucía Ruiz-Roca; Deborah Ingenhag; Alba Rodríguez-Meira; Franziska Auer; Arndt Borkhardt; Isidro Sánchez-García

doi:10.1016/j.semcancer.2014.02.001

Tumoral stem cell reprogramming as a driver of cancer: Theory, biological models, implications in cancer therapy

Carolina Vicente-Dueñas
, Julia Hauer
, Lucía Ruiz-Roca
, Deborah Ingenhag
, Alba Rodríguez-Meira
, Franziska Auer
, Arndt Borkhardt
, Isidro Sánchez-García

Universidad de Salamanca
Institute of Biomedical Research of Salamanca (IBSAL)
Medical Faculty and University Hospital Düsseldorf

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Cancer is a clonal malignant disease originated in a single cell and characterized by the accumulation of partially differentiated cells that are phenotypically reminiscent of normal stages of differentiation. According to current models, therapeutic strategies that block oncogene activity are likely to selectively target tumor cells. However, recent evidences have revealed that cancer stem cells could arise through a tumor stem cell reprogramming mechanism, suggesting that genetic lesions that initiate the cancer process might be dispensable for tumor progression and maintenance. This review addresses the impact of these results toward a better understanding of cancer development and proposes new approaches to treat cancer in the future.

Original language	English
Pages (from-to)	3-9
Number of pages	7
Journal	Seminars in Cancer Biology
Volume	32
DOIs	https://doi.org/10.1016/j.semcancer.2014.02.001
State	Published - 1 Jun 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer stem cell
Mouse model
Oncogenes
Stem cells
Tumoral reprogramming

Access to Document

10.1016/j.semcancer.2014.02.001

Cite this

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title = "Tumoral stem cell reprogramming as a driver of cancer: Theory, biological models, implications in cancer therapy",

abstract = "Cancer is a clonal malignant disease originated in a single cell and characterized by the accumulation of partially differentiated cells that are phenotypically reminiscent of normal stages of differentiation. According to current models, therapeutic strategies that block oncogene activity are likely to selectively target tumor cells. However, recent evidences have revealed that cancer stem cells could arise through a tumor stem cell reprogramming mechanism, suggesting that genetic lesions that initiate the cancer process might be dispensable for tumor progression and maintenance. This review addresses the impact of these results toward a better understanding of cancer development and proposes new approaches to treat cancer in the future.",

keywords = "Cancer stem cell, Mouse model, Oncogenes, Stem cells, Tumoral reprogramming",

author = "Carolina Vicente-Due{\~n}as and Julia Hauer and Luc{\'i}a Ruiz-Roca and Deborah Ingenhag and Alba Rodr{\'i}guez-Meira and Franziska Auer and Arndt Borkhardt and Isidro S{\'a}nchez-Garc{\'i}a",

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doi = "10.1016/j.semcancer.2014.02.001",

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T1 - Tumoral stem cell reprogramming as a driver of cancer

T2 - Theory, biological models, implications in cancer therapy

AU - Vicente-Dueñas, Carolina

AU - Hauer, Julia

AU - Ruiz-Roca, Lucía

AU - Ingenhag, Deborah

AU - Rodríguez-Meira, Alba

AU - Auer, Franziska

AU - Borkhardt, Arndt

AU - Sánchez-García, Isidro

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Cancer is a clonal malignant disease originated in a single cell and characterized by the accumulation of partially differentiated cells that are phenotypically reminiscent of normal stages of differentiation. According to current models, therapeutic strategies that block oncogene activity are likely to selectively target tumor cells. However, recent evidences have revealed that cancer stem cells could arise through a tumor stem cell reprogramming mechanism, suggesting that genetic lesions that initiate the cancer process might be dispensable for tumor progression and maintenance. This review addresses the impact of these results toward a better understanding of cancer development and proposes new approaches to treat cancer in the future.

AB - Cancer is a clonal malignant disease originated in a single cell and characterized by the accumulation of partially differentiated cells that are phenotypically reminiscent of normal stages of differentiation. According to current models, therapeutic strategies that block oncogene activity are likely to selectively target tumor cells. However, recent evidences have revealed that cancer stem cells could arise through a tumor stem cell reprogramming mechanism, suggesting that genetic lesions that initiate the cancer process might be dispensable for tumor progression and maintenance. This review addresses the impact of these results toward a better understanding of cancer development and proposes new approaches to treat cancer in the future.

KW - Cancer stem cell

KW - Mouse model

KW - Oncogenes

KW - Stem cells

KW - Tumoral reprogramming

UR - https://www.scopus.com/pages/publications/84929953179

U2 - 10.1016/j.semcancer.2014.02.001

DO - 10.1016/j.semcancer.2014.02.001

M3 - Review article

C2 - 24530939

AN - SCOPUS:84929953179

SN - 1044-579X

VL - 32

SP - 3

EP - 9

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

ER -

Tumoral stem cell reprogramming as a driver of cancer: Theory, biological models, implications in cancer therapy

Abstract

UN SDGs

Keywords

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