TY - JOUR
T1 - Tumor-associated overexpression of the soluble T1-S receptor in lymph node-negative breast cancer
AU - Werenskiold, Anne Katrin
AU - Prechtel, Dieter
AU - Harbeck, Nadia
AU - Höfler, Heinz
PY - 2000/3
Y1 - 2000/3
N2 - The oncogene-inducible secreted T1-S glycoprotein is overexpressed in invasive breast carcinomas in mice. As yet, nothing is known about the expression of T1-S in spontaneously occurring human cancers. A report follows on the overexpression of T1-S mRNA in 67% of primary invasive lymph node-negative breast carcinomas (31 of 46 patients) as determined by quantitative reverse transcriptase polymerase chain reaction. Overexpression of T1-S mRNA was independent of the tumor size, the histologic tumor type, and the estrogen - and progesterone-receptor status but was associated with high to moderate differentiation of the tumors (G1, G2). T1-S mRNA levels were low to nondetectable in resting normal mammary tissue and benign fibrocystic disease of the breast. Immunohistochemistry confirmed a low to moderate T1 immunoreactivity in epithelial cells of resting mammary tissue and benign fibrocystic disease and highly variable levels of T1 immunoreactivity in breast carcinoma cells. Kaplan-Meier analysis of disease-free survival during a median observation period of 61 months revealed a trend toward a reduced relapse rate and an extended relapse-free survival period for T1-S mRNA-overexpressing breast carcinomas. It is concluded that overexpression of T1-S receptor in lymph node-negative breast cancer may be a potential indicator for tumors with a low metastatic potential.
AB - The oncogene-inducible secreted T1-S glycoprotein is overexpressed in invasive breast carcinomas in mice. As yet, nothing is known about the expression of T1-S in spontaneously occurring human cancers. A report follows on the overexpression of T1-S mRNA in 67% of primary invasive lymph node-negative breast carcinomas (31 of 46 patients) as determined by quantitative reverse transcriptase polymerase chain reaction. Overexpression of T1-S mRNA was independent of the tumor size, the histologic tumor type, and the estrogen - and progesterone-receptor status but was associated with high to moderate differentiation of the tumors (G1, G2). T1-S mRNA levels were low to nondetectable in resting normal mammary tissue and benign fibrocystic disease of the breast. Immunohistochemistry confirmed a low to moderate T1 immunoreactivity in epithelial cells of resting mammary tissue and benign fibrocystic disease and highly variable levels of T1 immunoreactivity in breast carcinoma cells. Kaplan-Meier analysis of disease-free survival during a median observation period of 61 months revealed a trend toward a reduced relapse rate and an extended relapse-free survival period for T1-S mRNA-overexpressing breast carcinomas. It is concluded that overexpression of T1-S receptor in lymph node-negative breast cancer may be a potential indicator for tumors with a low metastatic potential.
KW - Disease-free survival
KW - Interleukin-1 receptor
KW - Metastasis
KW - Neoplasm
KW - Prognosis
UR - http://www.scopus.com/inward/record.url?scp=0034104216&partnerID=8YFLogxK
U2 - 10.1097/00019606-200003000-00005
DO - 10.1097/00019606-200003000-00005
M3 - Article
C2 - 10718210
AN - SCOPUS:0034104216
SN - 1052-9551
VL - 9
SP - 26
EP - 34
JO - Diagnostic Molecular Pathology
JF - Diagnostic Molecular Pathology
IS - 1
ER -