Tumor-associated overexpression of the soluble T1-S receptor in lymph node-negative breast cancer

Anne Katrin Werenskiold, Dieter Prechtel, Nadia Harbeck, Heinz Höfler

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The oncogene-inducible secreted T1-S glycoprotein is overexpressed in invasive breast carcinomas in mice. As yet, nothing is known about the expression of T1-S in spontaneously occurring human cancers. A report follows on the overexpression of T1-S mRNA in 67% of primary invasive lymph node-negative breast carcinomas (31 of 46 patients) as determined by quantitative reverse transcriptase polymerase chain reaction. Overexpression of T1-S mRNA was independent of the tumor size, the histologic tumor type, and the estrogen - and progesterone-receptor status but was associated with high to moderate differentiation of the tumors (G1, G2). T1-S mRNA levels were low to nondetectable in resting normal mammary tissue and benign fibrocystic disease of the breast. Immunohistochemistry confirmed a low to moderate T1 immunoreactivity in epithelial cells of resting mammary tissue and benign fibrocystic disease and highly variable levels of T1 immunoreactivity in breast carcinoma cells. Kaplan-Meier analysis of disease-free survival during a median observation period of 61 months revealed a trend toward a reduced relapse rate and an extended relapse-free survival period for T1-S mRNA-overexpressing breast carcinomas. It is concluded that overexpression of T1-S receptor in lymph node-negative breast cancer may be a potential indicator for tumors with a low metastatic potential.

Original languageEnglish
Pages (from-to)26-34
Number of pages9
JournalDiagnostic Molecular Pathology
Volume9
Issue number1
DOIs
StatePublished - Mar 2000

Keywords

  • Disease-free survival
  • Interleukin-1 receptor
  • Metastasis
  • Neoplasm
  • Prognosis

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