TH17 cells in the big picture of immunology

Carsten B. Schmidt-Weber, Mübeccel Akdis, Cezmi A. Akdis

Research output: Contribution to journalArticlepeer-review

238 Scopus citations

Abstract

The pathogenesis of chronic inflammatory diseases is assumed to depend on activated T cells interacting with resident tissue cells or migratory inflammatory cells. The discovery of new T-cell subsets such as the IL-17-producing TH17 and T-regulatory cells innovated our understanding of T-cell biology. Studies on new subsets confirm the important role of T cells in the instruction of tissue cells and also demonstrate the important role of feedback regulation for the polarization toward distinct T-cell subsets. The understanding of IL-17 and TH17 differentiation pathways has also changed the perspective of immunologists regarding the basis of chronic tissue inflammation, particularly where TH1 cells were considered as driving force of the pathology. This review summarizes the recent developments on TH cell subsets and integrates these findings into existing concepts of immunopathologic mechanisms.

Original languageEnglish
Pages (from-to)247-254
Number of pages8
JournalJournal of Allergy and Clinical Immunology
Volume120
Issue number2
DOIs
StatePublished - Aug 2007
Externally publishedYes

Keywords

  • T17
  • T2
  • Tolerance
  • allergy
  • differentiation
  • transcription factor

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