Trophoblast Cell Surface Antigen 2 (Trop2) in Chromophobe Renal Cell Carcinoma

Marie Mikuteit; Sandra Steffens; Stefanie Zschäbitz; Michael Autenrieth; Wilko Weichert; Arndt Hartmann; Franziska Erlmeier

doi:10.1159/000522592

Trophoblast Cell Surface Antigen 2 (Trop2) in Chromophobe Renal Cell Carcinoma

Marie Mikuteit, Sandra Steffens, Stefanie Zschäbitz, Michael Autenrieth, Wilko Weichert, Arndt Hartmann, Franziska Erlmeier

Chair of Pathology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Overexpression of tumor-associated calcium signal transducer 2 (Trop2) is found in many tumor entities. The prognostic value of Trop2 in renal cell renal carcinoma (RCC), especially in nonclear cell RCC, is still unclear. Aim: The aim of this study was to evaluate the prognostic impact of Trop2 expression in a large cohort of patients with chromophobe (ch)RCC. Materials and Methods: Patients who underwent renal surgery due to chRCC were retrospectively evaluated. Tumor specimens were analyzed for Trop2 expression by immunohistochemistry. Results: Eighty-one chRCC patients were eligible for analysis, of these 24 (29.6%) patients were positive for Trop2. No significant associations were found for Trop2 expression and clinical attributes in patients with chRCC. The Kaplan-Meier analysis revealed no differences in 5-year overall survival for Trop2- compared to Trop2+ (89.6% vs. 100.0%; p = 0.288). Conclusion: In chRCC, Trop2 expression is not associated with survival and other parameters of aggressiveness. Due to the rare incidence of chRCC, further studies with larger cohorts are warranted.

Original language	English
Pages (from-to)	331-336
Number of pages	6
Journal	Oncology
Volume	100
Issue number	6
DOIs	https://doi.org/10.1159/000522592
State	Published - 1 May 2022

Keywords

Renal cell carcinoma
Survival
Trophoblast cell surface antigen 2
hromophobe histology

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10.1159/000522592

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@article{ceaa4a42a3d34513a20f0de7c0641288,

title = "Trophoblast Cell Surface Antigen 2 (Trop2) in Chromophobe Renal Cell Carcinoma",

abstract = "Background: Overexpression of tumor-associated calcium signal transducer 2 (Trop2) is found in many tumor entities. The prognostic value of Trop2 in renal cell renal carcinoma (RCC), especially in nonclear cell RCC, is still unclear. Aim: The aim of this study was to evaluate the prognostic impact of Trop2 expression in a large cohort of patients with chromophobe (ch)RCC. Materials and Methods: Patients who underwent renal surgery due to chRCC were retrospectively evaluated. Tumor specimens were analyzed for Trop2 expression by immunohistochemistry. Results: Eighty-one chRCC patients were eligible for analysis, of these 24 (29.6%) patients were positive for Trop2. No significant associations were found for Trop2 expression and clinical attributes in patients with chRCC. The Kaplan-Meier analysis revealed no differences in 5-year overall survival for Trop2- compared to Trop2+ (89.6% vs. 100.0%; p = 0.288). Conclusion: In chRCC, Trop2 expression is not associated with survival and other parameters of aggressiveness. Due to the rare incidence of chRCC, further studies with larger cohorts are warranted.",

keywords = "Renal cell carcinoma, Survival, Trophoblast cell surface antigen 2, hromophobe histology",

author = "Marie Mikuteit and Sandra Steffens and Stefanie Zsch{\"a}bitz and Michael Autenrieth and Wilko Weichert and Arndt Hartmann and Franziska Erlmeier",

note = "Publisher Copyright: {\textcopyright} 2022 ",

year = "2022",

month = may,

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doi = "10.1159/000522592",

language = "English",

volume = "100",

pages = "331--336",

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T1 - Trophoblast Cell Surface Antigen 2 (Trop2) in Chromophobe Renal Cell Carcinoma

AU - Mikuteit, Marie

AU - Steffens, Sandra

AU - Zschäbitz, Stefanie

AU - Autenrieth, Michael

AU - Weichert, Wilko

AU - Hartmann, Arndt

AU - Erlmeier, Franziska

PY - 2022/5/1

Y1 - 2022/5/1

N2 - Background: Overexpression of tumor-associated calcium signal transducer 2 (Trop2) is found in many tumor entities. The prognostic value of Trop2 in renal cell renal carcinoma (RCC), especially in nonclear cell RCC, is still unclear. Aim: The aim of this study was to evaluate the prognostic impact of Trop2 expression in a large cohort of patients with chromophobe (ch)RCC. Materials and Methods: Patients who underwent renal surgery due to chRCC were retrospectively evaluated. Tumor specimens were analyzed for Trop2 expression by immunohistochemistry. Results: Eighty-one chRCC patients were eligible for analysis, of these 24 (29.6%) patients were positive for Trop2. No significant associations were found for Trop2 expression and clinical attributes in patients with chRCC. The Kaplan-Meier analysis revealed no differences in 5-year overall survival for Trop2- compared to Trop2+ (89.6% vs. 100.0%; p = 0.288). Conclusion: In chRCC, Trop2 expression is not associated with survival and other parameters of aggressiveness. Due to the rare incidence of chRCC, further studies with larger cohorts are warranted.

AB - Background: Overexpression of tumor-associated calcium signal transducer 2 (Trop2) is found in many tumor entities. The prognostic value of Trop2 in renal cell renal carcinoma (RCC), especially in nonclear cell RCC, is still unclear. Aim: The aim of this study was to evaluate the prognostic impact of Trop2 expression in a large cohort of patients with chromophobe (ch)RCC. Materials and Methods: Patients who underwent renal surgery due to chRCC were retrospectively evaluated. Tumor specimens were analyzed for Trop2 expression by immunohistochemistry. Results: Eighty-one chRCC patients were eligible for analysis, of these 24 (29.6%) patients were positive for Trop2. No significant associations were found for Trop2 expression and clinical attributes in patients with chRCC. The Kaplan-Meier analysis revealed no differences in 5-year overall survival for Trop2- compared to Trop2+ (89.6% vs. 100.0%; p = 0.288). Conclusion: In chRCC, Trop2 expression is not associated with survival and other parameters of aggressiveness. Due to the rare incidence of chRCC, further studies with larger cohorts are warranted.

KW - Renal cell carcinoma

KW - Survival

KW - Trophoblast cell surface antigen 2

KW - hromophobe histology

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DO - 10.1159/000522592

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AN - SCOPUS:85130864116

SN - 0030-2414

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SP - 331

EP - 336

JO - Oncology

JF - Oncology

IS - 6

ER -

Trophoblast Cell Surface Antigen 2 (Trop2) in Chromophobe Renal Cell Carcinoma

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Keywords

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