Treatment of adductor spasticity with BTX-A in children with CP: A randomized, double-blind, placebo-controlled study

Volker Mall; Florian Heinen; Andrea Siebel; Christoph Bertram; Ulrich Hafkemeyer; Jörg Wissel; Steffen Berweck; Fritz Haverkamp; Günter Nass; Leo Döderlein; Nico Breitbach-Faller; Wilhelm Schulte-Mattler; Rudolf Korinthenberg

doi:10.1017/S0012162206000041

Treatment of adductor spasticity with BTX-A in children with CP: A randomized, double-blind, placebo-controlled study

Volker Mall
, Florian Heinen
, Andrea Siebel
, Christoph Bertram
, Ulrich Hafkemeyer
, Jörg Wissel
, Steffen Berweck
, Fritz Haverkamp
, Günter Nass
, Leo Döderlein
, Nico Breitbach-Faller
, Wilhelm Schulte-Mattler
, Rudolf Korinthenberg

University of Freiburg
University of Munich
Bruker Optik GmbH
University of Cologne
University of Münster
University of Innsbruck
University of Bonn and University Hospital Bonn
Department of Child Neurology
Heidelberg University
Children's Hospital
University of Regensburg

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

Adductor spasticity in children with cerebral palsy (CP) impairs motor function and development. In a placebo-controlled, double-blind, randomized multicentre study, we evaluated the effects of botulinum toxin A(BTX-A) in 61 children (37 males, 24 females; mean age 6 years 1 month [SD 3y 1mo]) with CP (leg-dominated tetraparesis, n=39; tetraparesis, n=22; GMFCS level I, n=3; II, n=6; III, n=17; IV, n=29; V, n=6). Four weeks after treatment, a significant superiority of BTX-A was observed in the primary outcome measure (knee-knee distance 'fast catch', p=0.002), the Ashworth scale (p=0.001), and the Goal Attainment Scale (p=0.037).

Original language	English
Pages (from-to)	10-13
Number of pages	4
Journal	Developmental Medicine and Child Neurology
Volume	48
Issue number	1
DOIs	https://doi.org/10.1017/S0012162206000041
State	Published - Jan 2006
Externally published	Yes

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Mall, V., Heinen, F., Siebel, A., Bertram, C., Hafkemeyer, U., Wissel, J., Berweck, S., Haverkamp, F., Nass, G., Döderlein, L., Breitbach-Faller, N., Schulte-Mattler, W., & Korinthenberg, R. (2006). Treatment of adductor spasticity with BTX-A in children with CP: A randomized, double-blind, placebo-controlled study. Developmental Medicine and Child Neurology, 48(1), 10-13. https://doi.org/10.1017/S0012162206000041

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title = "Treatment of adductor spasticity with BTX-A in children with CP: A randomized, double-blind, placebo-controlled study",

abstract = "Adductor spasticity in children with cerebral palsy (CP) impairs motor function and development. In a placebo-controlled, double-blind, randomized multicentre study, we evaluated the effects of botulinum toxin A(BTX-A) in 61 children (37 males, 24 females; mean age 6 years 1 month [SD 3y 1mo]) with CP (leg-dominated tetraparesis, n=39; tetraparesis, n=22; GMFCS level I, n=3; II, n=6; III, n=17; IV, n=29; V, n=6). Four weeks after treatment, a significant superiority of BTX-A was observed in the primary outcome measure (knee-knee distance 'fast catch', p=0.002), the Ashworth scale (p=0.001), and the Goal Attainment Scale (p=0.037).",

author = "Volker Mall and Florian Heinen and Andrea Siebel and Christoph Bertram and Ulrich Hafkemeyer and J{\"o}rg Wissel and Steffen Berweck and Fritz Haverkamp and G{\"u}nter Nass and Leo D{\"o}derlein and Nico Breitbach-Faller and Wilhelm Schulte-Mattler and Rudolf Korinthenberg",

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doi = "10.1017/S0012162206000041",

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Mall, V, Heinen, F, Siebel, A, Bertram, C, Hafkemeyer, U, Wissel, J, Berweck, S, Haverkamp, F, Nass, G, Döderlein, L, Breitbach-Faller, N, Schulte-Mattler, W & Korinthenberg, R 2006, 'Treatment of adductor spasticity with BTX-A in children with CP: A randomized, double-blind, placebo-controlled study', Developmental Medicine and Child Neurology, vol. 48, no. 1, pp. 10-13. https://doi.org/10.1017/S0012162206000041

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AU - Mall, Volker

AU - Heinen, Florian

AU - Siebel, Andrea

AU - Bertram, Christoph

AU - Hafkemeyer, Ulrich

AU - Wissel, Jörg

AU - Berweck, Steffen

AU - Haverkamp, Fritz

AU - Nass, Günter

AU - Döderlein, Leo

AU - Breitbach-Faller, Nico

AU - Schulte-Mattler, Wilhelm

AU - Korinthenberg, Rudolf

PY - 2006/1

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N2 - Adductor spasticity in children with cerebral palsy (CP) impairs motor function and development. In a placebo-controlled, double-blind, randomized multicentre study, we evaluated the effects of botulinum toxin A(BTX-A) in 61 children (37 males, 24 females; mean age 6 years 1 month [SD 3y 1mo]) with CP (leg-dominated tetraparesis, n=39; tetraparesis, n=22; GMFCS level I, n=3; II, n=6; III, n=17; IV, n=29; V, n=6). Four weeks after treatment, a significant superiority of BTX-A was observed in the primary outcome measure (knee-knee distance 'fast catch', p=0.002), the Ashworth scale (p=0.001), and the Goal Attainment Scale (p=0.037).

AB - Adductor spasticity in children with cerebral palsy (CP) impairs motor function and development. In a placebo-controlled, double-blind, randomized multicentre study, we evaluated the effects of botulinum toxin A(BTX-A) in 61 children (37 males, 24 females; mean age 6 years 1 month [SD 3y 1mo]) with CP (leg-dominated tetraparesis, n=39; tetraparesis, n=22; GMFCS level I, n=3; II, n=6; III, n=17; IV, n=29; V, n=6). Four weeks after treatment, a significant superiority of BTX-A was observed in the primary outcome measure (knee-knee distance 'fast catch', p=0.002), the Ashworth scale (p=0.001), and the Goal Attainment Scale (p=0.037).

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IS - 1

ER -

Treatment of adductor spasticity with BTX-A in children with CP: A randomized, double-blind, placebo-controlled study

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